Discovery of energy transfer nanostructures using gelation-driven dynamic combinatorial libraries

Siva Krishna Mohan Nalluri, Rein V. Ulijn

Research output: Contribution to journalArticle

63 Citations (Scopus)
82 Downloads (Pure)

Abstract

Peptide self-assembly provides a useful approach to control the organization of functional molecular components, as relevant to future opto-electronic or photonic nanostructures. In this article, we report on the discovery of efficient energy transfer nanostructures using a dynamic combinatorial library (DCL) approach driven by molecular self-assembly, demonstrating an enhanced self-selection and amplification of effective energy transfer nanostructures from complex mixtures of dipeptide derivatives. By taking advantage of an enzyme-catalysed fully reversible amide formation reaction, we show how gelation shifts the equilibrium in favour of the formation of short aromatic dipeptide derivatives in the DCL system, as confirmed by reversed-phase high pressure liquid chromatography (HPLC), fluorescence emission spectroscopy, atomic force microscopy (AFM), transmission force microscopy (TEM) and circular dichroism (CD) spectroscopy. This approach enabled us to identify a two-component donor-acceptor hydrogel, which forms within minutes and exhibits efficient energy transfer.
Original languageEnglish
Pages (from-to)3699-3705
Number of pages7
JournalChemical Science
Volume4
Issue number9
Early online date2 Jul 2013
DOIs
Publication statusPublished - 2013

Keywords

  • dynamic combinatorial library
  • energy transfer nanostructures
  • high pressure liquid chromatography
  • fluorescence emission spectroscopy
  • transmission force microscopy

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