Discovery and recovery of delta p-aminobenzoic acid

Martin R. Ward, Shatha Younis, Aurora J. Cruz-Cabeza, Craig L. Bull, Nicholas P. Funnell, Iain D. H. Oswald

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We explore the polymorphism of p-aminobenzoic acid (pABA) under high-pressure conditions. We have been able to isolate a new high-pressure form (δ-pABA) at pressures exceeding 0.3 GPa from three different pressure-transmitting media, water, water:ethanol and pure ethanol. We explore the compression behaviour of α-pABA in each of these media using neutron powder diffraction and observe that the transition is kinetically hindered using the aqueous ethanol and ethanol solutions compared with the pure aqueous medium. δ-pABA is sufficiently stable to be recovered to ambient pressure to enable its characterisation via X-ray powder diffraction and differential scanning calorimetry. At ambient pressure we have observed that δ-pABA converts into α-pABA on heating beyond 70 °C.
LanguageEnglish
Pages2058-2066
Number of pages9
JournalCrystEngComm
Volume21
Issue number13
Early online date21 Jan 2019
DOIs
Publication statusPublished - 7 Apr 2019

Fingerprint

4-Aminobenzoic Acid
recovery
Pressure
Recovery
acids
Acids
Ethanol
ethyl alcohol
Powder Diffraction
Neutron Diffraction
Neutron powder diffraction
Water
polymorphism
Differential Scanning Calorimetry
Polymorphism
diffraction
X-Ray Diffraction
X ray powder diffraction
Heating
water

Keywords

  • p-aminobenzoic acid
  • neutron powder diffraction
  • high pressure
  • recovery

Cite this

Ward, M. R., Younis, S., Cruz-Cabeza, A. J., Bull, C. L., Funnell, N. P., & Oswald, I. D. H. (2019). Discovery and recovery of delta p-aminobenzoic acid. CrystEngComm, 21(13), 2058-2066. https://doi.org/10.1039/C8CE01882K
Ward, Martin R. ; Younis, Shatha ; Cruz-Cabeza, Aurora J. ; Bull, Craig L. ; Funnell, Nicholas P. ; Oswald, Iain D. H. / Discovery and recovery of delta p-aminobenzoic acid. In: CrystEngComm. 2019 ; Vol. 21, No. 13. pp. 2058-2066.
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Ward, MR, Younis, S, Cruz-Cabeza, AJ, Bull, CL, Funnell, NP & Oswald, IDH 2019, 'Discovery and recovery of delta p-aminobenzoic acid' CrystEngComm, vol. 21, no. 13, pp. 2058-2066. https://doi.org/10.1039/C8CE01882K

Discovery and recovery of delta p-aminobenzoic acid. / Ward, Martin R.; Younis, Shatha; Cruz-Cabeza, Aurora J.; Bull, Craig L.; Funnell, Nicholas P.; Oswald, Iain D. H.

In: CrystEngComm, Vol. 21, No. 13, 07.04.2019, p. 2058-2066.

Research output: Contribution to journalArticle

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Ward MR, Younis S, Cruz-Cabeza AJ, Bull CL, Funnell NP, Oswald IDH. Discovery and recovery of delta p-aminobenzoic acid. CrystEngComm. 2019 Apr 7;21(13):2058-2066. https://doi.org/10.1039/C8CE01882K