Abstract
A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.
Original language | English |
---|---|
Number of pages | 6 |
Journal | Synlett |
Early online date | 5 Feb 2024 |
DOIs | |
Publication status | E-pub ahead of print - 5 Feb 2024 |
Keywords
- iridium catalysis
- hydrogen isotope exchange
- deuteration
- carboxylic acids
- benzoic acids