Directing hydrogen isotope exchange with aryl carboxylic acids

Richard J. Mudd; Marc Reid; Laura C. Paterson; Jens Atzrodt; Volker Derdau; William J. Kerr

doi:10.1055/a-2239-6965

Directing hydrogen isotope exchange with aryl carboxylic acids

Richard J. Mudd, Marc Reid, Laura C. Paterson, Jens Atzrodt, Volker Derdau, William J. Kerr^*

^*Corresponding author for this work

University Of Strathclyde

Research output: Contribution to journal › Article › peer-review

Abstract

A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

Original language	English
Number of pages	6
Journal	Synlett
Early online date	5 Feb 2024
DOIs	https://doi.org/10.1055/a-2239-6965
Publication status	E-pub ahead of print - 5 Feb 2024

Keywords

iridium catalysis
hydrogen isotope exchange
deuteration
carboxylic acids
benzoic acids

Access to Document

10.1055/a-2239-6965

Embargoed Document

Mudd-etal-Synlett-2024-Directing-hydrogen-isotope-exchange-with-aryl-carboxylic-acids
Accepted author manuscript, 2.92 MB
Licence: Strath_1
Embargo ends: 5/02/25

Cite this

@article{f789d705c9504654b8d44a714b3e5883,

title = "Directing hydrogen isotope exchange with aryl carboxylic acids",

abstract = "A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.",

keywords = "iridium catalysis, hydrogen isotope exchange, deuteration, carboxylic acids, benzoic acids",

author = "Mudd, {Richard J.} and Marc Reid and Paterson, {Laura C.} and Jens Atzrodt and Volker Derdau and Kerr, {William J.}",

year = "2024",

month = feb,

day = "5",

doi = "10.1055/a-2239-6965",

language = "English",

journal = "Synlett",

issn = "0936-5214",

}

TY - JOUR

T1 - Directing hydrogen isotope exchange with aryl carboxylic acids

AU - Mudd, Richard J.

AU - Reid, Marc

AU - Paterson, Laura C.

AU - Atzrodt, Jens

AU - Derdau, Volker

AU - Kerr, William J.

PY - 2024/2/5

Y1 - 2024/2/5

N2 - A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

AB - A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

KW - iridium catalysis

KW - hydrogen isotope exchange

KW - deuteration

KW - carboxylic acids

KW - benzoic acids

U2 - 10.1055/a-2239-6965

DO - 10.1055/a-2239-6965

M3 - Article

AN - SCOPUS:85182445730

SN - 0936-5214

JO - Synlett

JF - Synlett

ER -

Directing hydrogen isotope exchange with aryl carboxylic acids

Abstract

Keywords

Access to Document

Embargoed Document

Fingerprint

Cite this