Directed meta-metalation using alkali-metal-mediated zincation

R.E. Mulvey, David R. Armstrong, W. Clegg, E. Hevia, S.H. Dale, L.M. Hogg, G.W. Honeyman

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon or
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
Original languageEnglish
Pages (from-to)3775-3778
Number of pages4
JournalAngewandte Chemie
Publication statusPublished - 2006


  • anilides
  • sodium
  • metalation
  • deprotonation

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