Directed meta-metalation using alkali-metal-mediated zincation

R.E. Mulvey, David R. Armstrong, W. Clegg, E. Hevia, S.H. Dale, L.M. Hogg, G.W. Honeyman

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon or
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
LanguageEnglish
Pages3775-3778
Number of pages4
JournalAngewandte Chemie
Volume45
DOIs
Publication statusPublished - 2006

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Alkali Metals
Alkali metals
Carbon
Hydrogen
Metals
Organic compounds
Cations
Protons
Hydrogen bonds
Positive ions
Atoms

Keywords

  • anilides
  • sodium
  • metalation
  • deprotonation

Cite this

Mulvey, R. E., Armstrong, D. R., Clegg, W., Hevia, E., Dale, S. H., Hogg, L. M., & Honeyman, G. W. (2006). Directed meta-metalation using alkali-metal-mediated zincation. Angewandte Chemie, 45, 3775-3778. https://doi.org/10.1002/anie.200600720
Mulvey, R.E. ; Armstrong, David R. ; Clegg, W. ; Hevia, E. ; Dale, S.H. ; Hogg, L.M. ; Honeyman, G.W. / Directed meta-metalation using alkali-metal-mediated zincation. In: Angewandte Chemie. 2006 ; Vol. 45. pp. 3775-3778.
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Mulvey, RE, Armstrong, DR, Clegg, W, Hevia, E, Dale, SH, Hogg, LM & Honeyman, GW 2006, 'Directed meta-metalation using alkali-metal-mediated zincation' Angewandte Chemie, vol. 45, pp. 3775-3778. https://doi.org/10.1002/anie.200600720

Directed meta-metalation using alkali-metal-mediated zincation. / Mulvey, R.E.; Armstrong, David R.; Clegg, W.; Hevia, E.; Dale, S.H.; Hogg, L.M.; Honeyman, G.W.

In: Angewandte Chemie, Vol. 45, 2006, p. 3775-3778.

Research output: Contribution to journalArticle

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