Abstract
Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon or
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
| Original language | English |
|---|---|
| Pages (from-to) | 3775-3778 |
| Number of pages | 4 |
| Journal | Angewandte Chemie |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 2006 |
Keywords
- anilides
- sodium
- metalation
- deprotonation
Fingerprint Dive into the research topics of 'Directed meta-metalation using alkali-metal-mediated zincation'. Together they form a unique fingerprint.
Cite this
Mulvey, R. E., Armstrong, D. R., Clegg, W., Hevia, E., Dale, S. H., Hogg, L. M., & Honeyman, G. W. (2006). Directed meta-metalation using alkali-metal-mediated zincation. Angewandte Chemie, 45, 3775-3778. https://doi.org/10.1002/anie.200600720