Abstract
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
| Language | English |
|---|---|
| Pages | 3775-3778 |
| Number of pages | 4 |
| Journal | Angewandte Chemie |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 2006 |
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Keywords
- anilides
- sodium
- metalation
- deprotonation
Cite this
}
Directed meta-metalation using alkali-metal-mediated zincation. / Mulvey, R.E.; Armstrong, David R.; Clegg, W.; Hevia, E.; Dale, S.H.; Hogg, L.M.; Honeyman, G.W.
In: Angewandte Chemie, Vol. 45, 2006, p. 3775-3778.Research output: Contribution to journal › Article
TY - JOUR
T1 - Directed meta-metalation using alkali-metal-mediated zincation
AU - Mulvey, R.E.
AU - Armstrong, David R.
AU - Clegg, W.
AU - Hevia, E.
AU - Dale, S.H.
AU - Hogg, L.M.
AU - Honeyman, G.W.
PY - 2006
Y1 - 2006
N2 - Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon orcarbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activatingfunctional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
AB - Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon orcarbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activatingfunctional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
KW - anilides
KW - sodium
KW - metalation
KW - deprotonation
UR - http://dx.doi.org/10.1002/anie.200600720
U2 - 10.1002/anie.200600720
DO - 10.1002/anie.200600720
M3 - Article
VL - 45
SP - 3775
EP - 3778
JO - Angewandte Chemie International Edition
T2 - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
ER -