Directed meta-metalation using alkali-metal-mediated zincation

R.E. Mulvey, David R. Armstrong, W. Clegg, E. Hevia, S.H. Dale, L.M. Hogg, G.W. Honeyman

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Transforming a carbon–hydrogen bond of an organic compound into a more useful, more reactive carbon–metal bond (so-called deprotonative metalation), which, in turn, can be treated with an electrophile to create a new carbon–carbon or
carbon–heteroatom bond, is one of the most fundamental synthetic approaches that chemists employ to construct compounds.[1, 2] Many of these reactions involve a special type of deprotonative metalation, in which an activating
functional group is positioned adjacent to the hydrogen atom (strictly a proton) that is to be replaced by the metal cation.
Original languageEnglish
Pages (from-to)3775-3778
Number of pages4
JournalAngewandte Chemie
Volume45
DOIs
Publication statusPublished - 2006

Keywords

  • anilides
  • sodium
  • metalation
  • deprotonation

Fingerprint Dive into the research topics of 'Directed meta-metalation using alkali-metal-mediated zincation'. Together they form a unique fingerprint.

  • Cite this

    Mulvey, R. E., Armstrong, D. R., Clegg, W., Hevia, E., Dale, S. H., Hogg, L. M., & Honeyman, G. W. (2006). Directed meta-metalation using alkali-metal-mediated zincation. Angewandte Chemie, 45, 3775-3778. https://doi.org/10.1002/anie.200600720