Direct preparation of benzofurans from O-arylhydroxylamines.

Fanny Contiero, Kevin M. Jones, Edward A. Matts, Achim Porzelle, Nicholas C. O. Tomkinson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Reaction of O-arylhydroxylamine hydrochlorides with either cyclic or acyclic ketones in the presence of methanesulfonic acid leads directly to the benzofuran deriv. via a proposed one-pot condensation-rearrangement-cyclization reaction sequence in good to excellent yields. E.g., in the presence of methanesulfonic acid, reaction of H2NOPh.HCl and cyclohexanone gave 70% benzofuran deriv. I.
Original languageUndefined/Unknown
Pages (from-to)3003-3006
Number of pages4
JournalSynlett
Issue number18
DOIs
Publication statusPublished - 2009

Keywords

  • benzofurans
  • O-arylhydroxylamines
  • hydrochlorides

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