Dioxo-triazines as a novel series of cathepsin K inhibitors

Zoran Rankovic, Jiaqiang Cai, Xavier Fradera, Maureen Dempster, Ashvin Mistry, Clive Long, Emma Hamilton, Angela King, Sylviane Boucharens, Craig Jamieson, Jonathan Gillespie, Iain Cumming, Joost Uitdehaag, Mario. van Zeeland

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


A novel dioxo-triazine series of cathepsin K inhibitors was identified from HTS. A rapid exploratory program led to the discovery of potent and selective cathepsin K inhibitors, typified by compd. 24 which displayed IC50 values of 17 nM against catK and >10,000 nM in catL, catB and catS assays.
Original languageEnglish
Pages (from-to)1488-1490
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number5
Publication statusPublished - 1 Mar 2010


  • cathepsin L
  • cysteine protease
  • osteoporosis


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