Diisopropylamide and TMP turbo-grignard reagents: a structural rationale for their contrasting reactivities

David R. Armstrong, Pablo Garcia-Álvarez, Alan R. Kennedy, Robert E. Mulvey, John A. Parkinson

Research output: Contribution to journalArticle

67 Citations (Scopus)
245 Downloads (Pure)

Abstract

A neutral dimeric molecule in crystal form, the diisopropylamido turbo-Grignard reagent "(iPr2N)MgCl⋅LiCl" (see structure; blue N, red O, green Mg, yellow Cl, black C) separates into several charged ate species in dynamic exchange with each other in THF solution as determined by a combination of EXSY and DOSY NMR studies.
Original languageEnglish
Pages (from-to)3185–3188
Number of pages4
JournalAngewandte Chemie International Edition
Volume49
Issue number18
Early online date29 Mar 2010
DOIs
Publication statusPublished - 19 Apr 2010

Keywords

  • amides
  • grignard reagents
  • metalation
  • structure elucidation
  • DOSY NMR spectroscopy

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