Abstract
| Language | English |
|---|---|
| Pages | 387-395 |
| Number of pages | 9 |
| Journal | European Journal of Vascular and Endovascular Surgery |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2000 |
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Keywords
- aged
- amputation
- arteries
- biopsy
- critical illness
- diabetes mellitus, type 1
- diabetes mellitus, type 2
- diabetic angiopathies
- female
- humans
- ischemia
- leg
- male
- muscle, skeletal
- myography
- skin
- vascular resistance
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Differential responses in human subcutaneous and skeletal muscle vascular beds to critical limb ischaemia. / Coats, P; Hillier, C.
In: European Journal of Vascular and Endovascular Surgery, Vol. 19, No. 4, 04.2000, p. 387-395.Research output: Contribution to journal › Article
TY - JOUR
T1 - Differential responses in human subcutaneous and skeletal muscle vascular beds to critical limb ischaemia
AU - Coats, P
AU - Hillier, C
PY - 2000/4
Y1 - 2000/4
N2 - Objectives to investigate the effects of chronic ischaemia on the subcutaneous and the skeletal muscle resistance vasculature. To understand the redistribution of available blood in the ischaemic limb. Methods human subcutaneous and skeletal muscle resistance arteries were obtained from limbs amputated for critical limb ischaemia and studied under isobaric conditions using pressure myography. Morphological measurements of wall and lumen were analysed using light microscopy and image analysis. Vasoconstrictor responses to potassium and adrenoceptor agonists were used to measure functional status. Noradrenaline re-uptake mechanisms and α1-selectivity were investigated. Results both human skeletal muscle and subcutaneous resistance arteries undergo a severe atrophy of the arterial wall in ischaemic conditions. However, whereas subcutaneous resistance arteries become less able to vasoconstrict to adrenoceptor stimulation, the response of skeletal muscle resistance arteries becomes exaggerated and significantly augmented. This is true in response to both the endogenous vasoconstrictor noradraline and the α1-selective adrenoceptor agonist phenylephrine. Conclusions hypersensitivity to circulating catecholamines in the skeletal muscle vascular resistance bed may contribute to the progression of ischaemic disease by differentially diverting available blood to the subcutaneous tissue to the detriment of skeletal muscle perfusion.
AB - Objectives to investigate the effects of chronic ischaemia on the subcutaneous and the skeletal muscle resistance vasculature. To understand the redistribution of available blood in the ischaemic limb. Methods human subcutaneous and skeletal muscle resistance arteries were obtained from limbs amputated for critical limb ischaemia and studied under isobaric conditions using pressure myography. Morphological measurements of wall and lumen were analysed using light microscopy and image analysis. Vasoconstrictor responses to potassium and adrenoceptor agonists were used to measure functional status. Noradrenaline re-uptake mechanisms and α1-selectivity were investigated. Results both human skeletal muscle and subcutaneous resistance arteries undergo a severe atrophy of the arterial wall in ischaemic conditions. However, whereas subcutaneous resistance arteries become less able to vasoconstrict to adrenoceptor stimulation, the response of skeletal muscle resistance arteries becomes exaggerated and significantly augmented. This is true in response to both the endogenous vasoconstrictor noradraline and the α1-selective adrenoceptor agonist phenylephrine. Conclusions hypersensitivity to circulating catecholamines in the skeletal muscle vascular resistance bed may contribute to the progression of ischaemic disease by differentially diverting available blood to the subcutaneous tissue to the detriment of skeletal muscle perfusion.
KW - aged
KW - amputation
KW - arteries
KW - biopsy
KW - critical illness
KW - diabetes mellitus, type 1
KW - diabetes mellitus, type 2
KW - diabetic angiopathies
KW - female
KW - humans
KW - ischemia
KW - leg
KW - male
KW - muscle, skeletal
KW - myography
KW - skin
KW - vascular resistance
U2 - 10.1053/ejvs.1999.1023
DO - 10.1053/ejvs.1999.1023
M3 - Article
VL - 19
SP - 387
EP - 395
JO - European Journal of Vascular and Endovascular Surgery
T2 - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
SN - 1078-5884
IS - 4
ER -