Differential regulation of protein subdomain activity with caged bivalent ligands

G. Mayer, J. Müller, T. Mack, D.F. Freitag, T. Höver, Bernd Pötzsch, A. Heckel

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile 'caging groups' to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light.
Original languageEnglish
Pages (from-to)654-657
Number of pages3
Issue number4
Publication statusPublished - 2009


  • aptamers
  • blood clotting
  • caged compounds
  • dna
  • molecular switches


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