TY - JOUR
T1 - Differential effect of substrate stiffness and adsorbed fibronectin density on vascular smooth muscle migration rate
AU - Whitton, A.
AU - Flint, D.J.
AU - Black, R.A.
PY - 2009
Y1 - 2009
N2 - Current surgical approaches to the treatment of patients with cardiovascular disease include the implantation of devices that aim to restore and maintain the flow of blood; however, the patency of such devices in the long term is limited by a physiological process called intimal hyperplasia (IH) or restenosis: the thickening of the vessel wall in response to injury.http://www.ecmjournal.orgThis study aims to investigate the effect of both the stiffness of the implanted material and the concentration of adsorbed proteins from the blood onto the material surface on the migration of the cells resident in the vessel wall; an important early stage in the progression of IH.
AB - Current surgical approaches to the treatment of patients with cardiovascular disease include the implantation of devices that aim to restore and maintain the flow of blood; however, the patency of such devices in the long term is limited by a physiological process called intimal hyperplasia (IH) or restenosis: the thickening of the vessel wall in response to injury.http://www.ecmjournal.orgThis study aims to investigate the effect of both the stiffness of the implanted material and the concentration of adsorbed proteins from the blood onto the material surface on the migration of the cells resident in the vessel wall; an important early stage in the progression of IH.
KW - cardiovascular disease
KW - differential effect
KW - substrate stiffness
KW - adsorbed fibronectin density
KW - vascular smooth muscle migration rate
KW - intimal hyperplasia (IH)
KW - restenosis
KW - injury
UR - http://www.ecmjournal.org/journal/supplements/vol018supp02/pdf/v018supp02a029.pdf
UR - http://www.ecmjournal.org/journal/supplements/vol018supp02/vol018supp02.htm
M3 - Conference Contribution
SN - 1473-2262
VL - 18
SP - 29
JO - European Cells and Materials
JF - European Cells and Materials
IS - Suppl.2
ER -
