Differential activity of rosiglitazone enantiomers at PPARγ

Derek J. Parks; Nicholas C. O. Tomkinson; Manon S. Villeneuve; Steven G. Blanchard; Timothy M. Willson

doi:10.1016/S0960-894X(98)00664-7

Differential activity of rosiglitazone enantiomers at PPARγ

Derek J. Parks, Nicholas C. O. Tomkinson, Manon S. Villeneuve, Steven G. Blanchard, Timothy M. Willson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

Original language	Undefined/Unknown
Pages (from-to)	3657-3658
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	24
DOIs	https://doi.org/10.1016/S0960-894X(98)00664-7
Publication status	Published - 1998

Keywords

rosiglitazone enantiomers
rosiglitazone
antidiabetic activity

Access to Document

10.1016/S0960-894X(98)00664-7

Cite this

@article{03572a1cd0424900bca3837f0f084c75,

title = "Differential activity of rosiglitazone enantiomers at PPARγ",

abstract = "Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.",

keywords = "rosiglitazone enantiomers , rosiglitazone , antidiabetic activity",

author = "Parks, {Derek J.} and Tomkinson, {Nicholas C. O.} and Villeneuve, {Manon S.} and Blanchard, {Steven G.} and Willson, {Timothy M.}",

year = "1998",

doi = "10.1016/S0960-894X(98)00664-7",

language = "Undefined/Unknown",

volume = "8",

pages = "3657--3658",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "24",

}

TY - JOUR

T1 - Differential activity of rosiglitazone enantiomers at PPARγ

AU - Parks, Derek J.

AU - Tomkinson, Nicholas C. O.

AU - Villeneuve, Manon S.

AU - Blanchard, Steven G.

AU - Willson, Timothy M.

PY - 1998

Y1 - 1998

N2 - Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

AB - Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.

KW - rosiglitazone enantiomers

KW - rosiglitazone

KW - antidiabetic activity

U2 - 10.1016/S0960-894X(98)00664-7

DO - 10.1016/S0960-894X(98)00664-7

M3 - Article

SN - 0960-894X

VL - 8

SP - 3657

EP - 3658

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -