Differential activity of rosiglitazone enantiomers at PPARγ

Derek J. Parks, Nicholas C. O. Tomkinson, Manon S. Villeneuve, Steven G. Blanchard, Timothy M. Willson

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Anal. of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the (S)-(-)- isomer is responsible for the antidiabetic activity.
Original languageUndefined/Unknown
Pages (from-to)3657-3658
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number24
DOIs
Publication statusPublished - 1998

Keywords

  • rosiglitazone enantiomers
  • rosiglitazone
  • antidiabetic activity

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