Dibromopyrrole alkaloids from the marine sponge acanthostylotella sp

Sherif S. Ebada, RuAngelie Edrada-Ebel, N.J. de Voogd, V. Wray, Peter Proksch

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13 Citations (Scopus)


Fourteen dibromopyrrole alkaloids were isolated from the marine sponge Acanthostylotella sp. collected in Indonesia. In addition to the known compounds 4,5-dibromo-N-(methoxy-methyl)-1H-pyrrole-2-carboxamide (7), 4,5-dibromo-1H-pyrrole-2-carboxamide (8), mukanadin D (9), (+/-)-longamide B methyl ester (10), (+/-)-longamide B (11), (+/-)-longamide (12), 3,4-dibromo-lH-pyrrole-2-carboxamide (13), 2-cyano-4,5-dibromo-1H-pyrrole (14), six compounds were isolated that proved to be new natural products including acanthamides A-D (1-4), methyl 3,4-dibromo-1H-pyrrole-2-carboxylate (5) and 3,5-dibromo-1H-pyrrole-2-carboxylic acid (6). The structures of the new compounds were unequivocally identified based on one and two dimensional NMR and on HRFTMS as well as by comparison with the literature.
Original languageEnglish
Pages (from-to)47-52
Number of pages5
JournalNatural Product Communications
Issue number1
Publication statusPublished - 2009


  • dibrominated alkaloids
  • acanthamide
  • acanthostylotella
  • pharmacology

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