Abstract
| Language | English |
|---|---|
| Pages | 1358-1364 |
| Number of pages | 6 |
| Journal | Journal of Natural Products |
| Volume | 71 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2008 |
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Keywords
- diacarperoxides
- norterpene cyclic peroxides
- sponges
- diacarnus megaspinorhabdosa
- plants
- pharmacology
- drugs
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Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa. / Ibraham, Sabrin; Ebel, Rainer; Wray, Victor; Muller, Werner E.G.; Edrada-Ebel, RuAngelie; Proksch, Peter.
In: Journal of Natural Products, Vol. 71, No. 8, 08.2008, p. 1358-1364.Research output: Contribution to journal › Article
TY - JOUR
T1 - Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa
AU - Ibraham, Sabrin
AU - Ebel, Rainer
AU - Wray, Victor
AU - Muller, Werner E.G.
AU - Edrada-Ebel, RuAngelie
AU - Proksch, Peter
PY - 2008/8
Y1 - 2008/8
N2 - Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2, C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties in vitro using several human as well as murine cancer cell lines.
AB - Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2, C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties in vitro using several human as well as murine cancer cell lines.
KW - diacarperoxides
KW - norterpene cyclic peroxides
KW - sponges
KW - diacarnus megaspinorhabdosa
KW - plants
KW - pharmacology
KW - drugs
UR - http://dx.doi.org/10.1021/np800102u
U2 - 10.1021/np800102u
DO - 10.1021/np800102u
M3 - Article
VL - 71
SP - 1358
EP - 1364
JO - Journal of Natural Products
T2 - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 8
ER -