Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones

William J. Kerr, Allan J. B. Watson, Douglas. Hayes

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Di-tert-butylmagnesium has been found to be a reactive, yet non-nucleophilic and non-reductive, carbon-centred base for the deprotonation of a series of ketones. This reagent demonstrates equally high reactivity when used as either the pre-formed reagent, or in a more accessible one-pot protocol from the parent Grignard reagent, and offers improved atom-efficiency over more traditionally employed bases.
Original languageEnglish
Pages (from-to)1386-1390
Number of pages5
JournalSynlett
Volume2008
Issue number9
DOIs
Publication statusPublished - 23 May 2008

Keywords

  • deprotonations
  • grignard reagents
  • ketones
  • magnesium
  • organometallic reagents

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