DHHC palmitoyl transferases: substrate interactions and (patho)physiology

Jennifer Greaves, Luke H Chamberlain

Research output: Contribution to journalArticlepeer-review

208 Citations (Scopus)


S-palmitoylation is a reversible post-translational modification that occurs on diverse cellular proteins. Palmitoylation can affect proteins in many different ways, including regulating membrane attachment, intracellular trafficking, and membrane micro-localisation. Intracellular palmitoylation reactions are mediated by a family of recently identified aspartate-histidine-histidine-cysteine (DHHC) palmitoyl transferases. More than 20 DHHC proteins are encoded by mammalian genomes, and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded. Recent studies have highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology.
Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - May 2011


  • S-palmitoylation
  • cellular proteins
  • intracellular trafficking
  • DHHC proteins

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