Development of transient myasthenia-like symptoms in chickens injected with acetylcholine receptor from Torpedo marmorata

T. Barkas, R. Harrison, G. G. Lunt, C. M. Watson, A. L. Harvey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

From the results obtained it appears that, although anti-(acetylcholine receptor) antibodies are produced in all chickens immunized with Torpedo receptor, myasthenia-like symptoms may only occur in those birds that develop a relatively rapid humoral response, and, even in these cases, the chickens eventually recover. The relative resistance of chickens to experimental autoimmune myasthenia gravis could clearly result from a number of factors. Some chicken muscles are known to be multiply innervated (Bowman & Marshall, 1971) and a relatively high number of acetylcholine receptors could contribute to resistance, as could a more rapid turnover of receptor and/or of immunoglobulins in chickens compared with other experimental animals.

Original languageEnglish
Pages (from-to)634-636
Number of pages3
JournalBiochemical Society Transactions
Volume6
Issue number3
DOIs
Publication statusPublished - 1 Jan 1978

Keywords

  • antibody
  • cholinergic receptor
  • humoral immunity
  • muscle
  • myasthenia gravis

Fingerprint Dive into the research topics of 'Development of transient myasthenia-like symptoms in chickens injected with acetylcholine receptor from Torpedo marmorata'. Together they form a unique fingerprint.

  • Cite this