Development of a sustainable catalytic ester amidation process

Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

Research output: Contribution to journalArticle

27 Citations (Scopus)
76 Downloads (Pure)

Abstract

We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).
Original languageEnglish
Pages (from-to)1339-1344
Number of pages6
JournalACS Sustainable Chemistry and Engineering
Volume1
Issue number10
Early online date30 Jul 2013
DOIs
Publication statusPublished - 7 Oct 2013

Fingerprint

ester
alcohol
Esters
Amino alcohols
Amino Alcohols
Derivatives
1-Propanol
Propanol
Design of experiments
Potassium
Screening
Phosphates
Alcohols
potassium
phosphate
methodology
experiment
potassium phosphate
screening
protocol

Keywords

  • sustainable ester amidation
  • amino alcohol
  • reaction mass efficiency
  • potassium phosphate

Cite this

Caldwell, Nicola ; Jamieson, Craig ; Simpson, Iain ; Watson, Allan J. B. / Development of a sustainable catalytic ester amidation process. In: ACS Sustainable Chemistry and Engineering. 2013 ; Vol. 1, No. 10. pp. 1339-1344.
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Development of a sustainable catalytic ester amidation process. / Caldwell, Nicola; Jamieson, Craig; Simpson, Iain; Watson, Allan J. B.

In: ACS Sustainable Chemistry and Engineering, Vol. 1, No. 10, 07.10.2013, p. 1339-1344.

Research output: Contribution to journalArticle

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