Development of a sustainable catalytic ester amidation process

Nicola Caldwell; Craig Jamieson; Iain Simpson; Allan J. B. Watson

doi:10.1021/sc400204g

Development of a sustainable catalytic ester amidation process

Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

Pure And Applied Chemistry

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Abstract

We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).

Original language	English
Pages (from-to)	1339-1344
Number of pages	6
Journal	ACS Sustainable Chemistry and Engineering
Volume	1
Issue number	10
Early online date	30 Jul 2013
DOIs	https://doi.org/10.1021/sc400204g
Publication status	Published - 7 Oct 2013

Keywords

sustainable ester amidation
amino alcohol
reaction mass efficiency
potassium phosphate

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10.1021/sc400204g

Jamieson-etal-ACSSC2013-development-of-a-sustainable-catalytic-ester-amidation-processAccepted author manuscript, 918 KB

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Development of a sustainable catalytic ester amidation process

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