We describe the development of a sustainable ester amidation process. Base and solvent screening, combined with the application of Design of Experiments methodology was employed to identify an optimized set of reaction conditions using a sustainable protocol. Utilizing these optimized conditions, treatment of a range of ester derivatives with amino alcohols in the presence of a catalytic quantity of potassium phosphate deploying iso-propanol as solvent results in the highly efficient generation of a range of amido-alcohol derivatives in good to excellent yield, accompanied with excellent reaction mass efficiency (RME).
- sustainable ester amidation
- amino alcohol
- reaction mass efficiency
- potassium phosphate
Caldwell, N., Jamieson, C., Simpson, I., & Watson, A. J. B. (2013). Development of a sustainable catalytic ester amidation process. ACS Sustainable Chemistry and Engineering, 1(10), 1339-1344. https://doi.org/10.1021/sc400204g