Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Fiona I. McGonagle; Donna S. MacMillan; Jane Murray; Helen F. Sneddon; Craig Jamieson; Allan J. B. Watson

doi:10.1039/c3gc40359a

Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Fiona I. McGonagle, Donna S. MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan J. B. Watson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

Original language	English
Pages (from-to)	1159-1165
Number of pages	7
Journal	Green Chemistry
Volume	15
Issue number	5
Early online date	9 Apr 2013
DOIs	https://doi.org/10.1039/c3gc40359a
Publication status	Published - 1 May 2013

Keywords

solvent selection
amination processes
borane-based reductants

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10.1039/c3gc40359a

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abstract = "A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.",

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AU - Watson, Allan J. B.

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Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Abstract

Keywords

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