Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Fiona I. McGonagle, Donna S. MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan J. B. Watson

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

LanguageEnglish
Pages1159-1165
Number of pages7
JournalGreen Chemistry
Volume15
Issue number5
Early online date9 Apr 2013
DOIs
Publication statusPublished - 1 May 2013

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Amination
aldehyde
Aldehydes
Boranes
Reducing Agents
replacement

Keywords

  • solvent selection
  • amination processes
  • borane-based reductants

Cite this

McGonagle, F. I., MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C., & Watson, A. J. B. (2013). Development of a solvent selection guide for aldehyde-based direct reductive amination processes. Green Chemistry, 15(5), 1159-1165. https://doi.org/10.1039/c3gc40359a
McGonagle, Fiona I. ; MacMillan, Donna S. ; Murray, Jane ; Sneddon, Helen F. ; Jamieson, Craig ; Watson, Allan J. B. / Development of a solvent selection guide for aldehyde-based direct reductive amination processes. In: Green Chemistry. 2013 ; Vol. 15, No. 5. pp. 1159-1165.
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McGonagle, FI, MacMillan, DS, Murray, J, Sneddon, HF, Jamieson, C & Watson, AJB 2013, 'Development of a solvent selection guide for aldehyde-based direct reductive amination processes' Green Chemistry, vol. 15, no. 5, pp. 1159-1165. https://doi.org/10.1039/c3gc40359a

Development of a solvent selection guide for aldehyde-based direct reductive amination processes. / McGonagle, Fiona I.; MacMillan, Donna S.; Murray, Jane; Sneddon, Helen F.; Jamieson, Craig; Watson, Allan J. B.

In: Green Chemistry, Vol. 15, No. 5, 01.05.2013, p. 1159-1165.

Research output: Contribution to journalArticle

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