Development of a solvent selection guide for aldehyde-based direct reductive amination processes

Fiona I. McGonagle, Donna S. MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan J. B. Watson

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Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

Original languageEnglish
Pages (from-to)1159-1165
Number of pages7
JournalGreen Chemistry
Volume15
Issue number5
Early online date9 Apr 2013
DOIs
Publication statusPublished - 1 May 2013

Keywords

  • solvent selection
  • amination processes
  • borane-based reductants

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    McGonagle, F. I., MacMillan, D. S., Murray, J., Sneddon, H. F., Jamieson, C., & Watson, A. J. B. (2013). Development of a solvent selection guide for aldehyde-based direct reductive amination processes. Green Chemistry, 15(5), 1159-1165. https://doi.org/10.1039/c3gc40359a