Abstract
| Language | English |
|---|---|
| Pages | 71-77 |
| Number of pages | 7 |
| Journal | European Journal of Pharmaceutical Sciences |
| Volume | 108 |
| Early online date | 12 Jun 2017 |
| DOIs | |
| Publication status | Published - 15 Oct 2017 |
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Keywords
- liposomes
- niosomes
- vesicles
- oral disintegrating tablets
- oral vaccines
- mannitol
- dextran
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Development of a solid dosage platform for the oral delivery of bilayer vesicles. / Wilkhu, Jitinder S.; McNeil, Sarah E.; Anderson, David E.; Kirchmeier, Marc; Perrie, Yvonne.
In: European Journal of Pharmaceutical Sciences, Vol. 108, 15.10.2017, p. 71-77.Research output: Contribution to journal › Article
TY - JOUR
T1 - Development of a solid dosage platform for the oral delivery of bilayer vesicles
AU - Wilkhu, Jitinder S.
AU - McNeil, Sarah E.
AU - Anderson, David E.
AU - Kirchmeier, Marc
AU - Perrie, Yvonne
PY - 2017/10/15
Y1 - 2017/10/15
N2 - Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.
AB - Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.
KW - liposomes
KW - niosomes
KW - vesicles
KW - oral disintegrating tablets
KW - oral vaccines
KW - mannitol
KW - dextran
UR - http://www.sciencedirect.com/science/journal/09280987?sdc=1
U2 - 10.1016/j.ejps.2017.06.014
DO - 10.1016/j.ejps.2017.06.014
M3 - Article
VL - 108
SP - 71
EP - 77
JO - European Journal of Pharmaceutical Sciences
T2 - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
SN - 0928-0987
ER -