Development of a solid dosage platform for the oral delivery of bilayer vesicles

Jitinder S. Wilkhu, Sarah E. McNeil, David E. Anderson, Marc Kirchmeier, Yvonne Perrie

Research output: Contribution to journalArticle

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37 Downloads (Pure)

Abstract

Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.
Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume108
Early online date12 Jun 2017
DOIs
Publication statusPublished - 15 Oct 2017

Keywords

  • liposomes
  • niosomes
  • vesicles
  • oral disintegrating tablets
  • oral vaccines
  • mannitol
  • dextran

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