Abstract
Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10 % mannitol and 10 % dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.
Original language | English |
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Pages (from-to) | 71-77 |
Number of pages | 7 |
Journal | European Journal of Pharmaceutical Sciences |
Volume | 108 |
Early online date | 12 Jun 2017 |
DOIs | |
Publication status | Published - 15 Oct 2017 |
Keywords
- liposomes
- niosomes
- vesicles
- oral disintegrating tablets
- oral vaccines
- mannitol
- dextran
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Development of a solid dosage platform for the oral delivery of bilayer vesicles
Perrie, Y. (Creator), University of Strathclyde, 13 Jun 2017
DOI: 10.15129/d70b34bc-abc4-4ffd-91a3-b0c05a8ab411
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