Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol

S. Ottoboni; C. J. Price; C. Steven; E. Meehan; A. Barton; A. Mitchell

Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol

S. Ottoboni, C. J. Price, C. Steven, E. Meehan, A. Barton, A. Mitchell

Research output: Contribution to conference › Proceeding

Abstract

The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

Original language	English
Number of pages	18
Publication status	Published - 13 Oct 2016
Event	Filtech - Koelnmesse, Cologne, Germany Duration: 11 Oct 2016 → 13 Oct 2016 http://www.filtech.de/pdfs/filtech2016_conference_programme.pdf

Conference

Conference	Filtech
Abbreviated title	Filtech 2016
Country/Territory	Germany
City	Cologne
Period	11/10/16 → 13/10/16
Internet address	http://www.filtech.de/pdfs/filtech2016_conference_programme.pdf

Keywords

continuous filtration
optimisation
impurity
agglomeration
drying
washing
purification

Cite this

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title = "Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol",

abstract = "The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.",

keywords = "continuous filtration, optimisation, impurity, agglomeration, drying, washing, purification",

author = "S. Ottoboni and Price, {C. J.} and C. Steven and E. Meehan and A. Barton and A. Mitchell",

year = "2016",

month = oct,

day = "13",

language = "English",

note = "Filtech, Filtech 2016 ; Conference date: 11-10-2016 Through 13-10-2016",

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TY - CONF

T1 - Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing

T2 - Filtech

AU - Ottoboni, S.

AU - Price, C. J.

AU - Steven, C.

AU - Meehan, E.

AU - Barton, A.

AU - Mitchell, A.

PY - 2016/10/13

Y1 - 2016/10/13

N2 - The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

AB - The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

KW - continuous filtration

KW - optimisation

KW - impurity

KW - agglomeration

KW - drying

KW - washing

KW - purification

UR - http://www.filtech.de/

UR - http://www.filtech.de/conference/conference-review/abstract-information?abstract_id=215

M3 - Proceeding

Y2 - 11 October 2016 through 13 October 2016

ER -

Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol

Abstract

Conference

Keywords

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Data for: "Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing"

Understanding and mitigating the consequences of undesired crystallisation taking place during washing of active pharmaceuticals

Addressing the challenges of continuous filtration, washing and drying