Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol

S. Ottoboni, C. J. Price, C. Steven, E. Meehan, A. Barton, A. Mitchell

Research output: Contribution to conferenceProceeding

Abstract

The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

Conference

ConferenceFiltech
Abbreviated titleFiltech 2016
CountryGermany
CityCologne
Period11/10/1613/10/16
Internet address

Fingerprint

Acetaminophen
Drug products
Equipment and Supplies
Drug Industry
Pharmaceutical Preparations
Processing
Industry

Keywords

  • continuous filtration
  • optimisation
  • impurity
  • agglomeration
  • drying
  • washing
  • purification

Cite this

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title = "Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol",
abstract = "The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.",
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author = "S. Ottoboni and Price, {C. J.} and C. Steven and E. Meehan and A. Barton and A. Mitchell",
year = "2016",
month = "10",
day = "13",
language = "English",
note = "Filtech, Filtech 2016 ; Conference date: 11-10-2016 Through 13-10-2016",
url = "http://www.filtech.de/pdfs/filtech2016_conference_programme.pdf",

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Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing : a case study using paracetamol. / Ottoboni, S.; Price, C. J.; Steven, C.; Meehan, E.; Barton, A.; Mitchell, A.

2016. Filtech, Cologne, Germany.

Research output: Contribution to conferenceProceeding

TY - CONF

T1 - Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing

T2 - a case study using paracetamol

AU - Ottoboni, S.

AU - Price, C. J.

AU - Steven, C.

AU - Meehan, E.

AU - Barton, A.

AU - Mitchell, A.

PY - 2016/10/13

Y1 - 2016/10/13

N2 - The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

AB - The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.

KW - continuous filtration

KW - optimisation

KW - impurity

KW - agglomeration

KW - drying

KW - washing

KW - purification

UR - http://www.filtech.de/

UR - http://www.filtech.de/conference/conference-review/abstract-information?abstract_id=215

M3 - Proceeding

ER -