Abstract
The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.
| Original language | English |
|---|---|
| Number of pages | 18 |
| Publication status | Published - 13 Oct 2016 |
| Event | Filtech - Koelnmesse, Cologne, Germany Duration: 11 Oct 2016 → 13 Oct 2016 http://www.filtech.de/pdfs/filtech2016_conference_programme.pdf |
Conference
| Conference | Filtech |
|---|---|
| Abbreviated title | Filtech 2016 |
| Country | Germany |
| City | Cologne |
| Period | 11/10/16 → 13/10/16 |
| Internet address |
Keywords
- continuous filtration
- optimisation
- impurity
- agglomeration
- drying
- washing
- purification
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Ottoboni, S., Price, C. J., Steven, C., Meehan, E., Barton, A., & Mitchell, A. (2016). Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol. Filtech, Cologne, Germany.