Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol

S. Ottoboni, C. J. Price, C. Steven, E. Meehan, A. Barton, A. Mitchell

Research output: Contribution to conferenceProceeding

Abstract

The pharmaceutical industry is starting to adopt continuous processing; however one missing component is an appropriately scaled unit for continuous isolation which can filter, wash and dry active pharmaceutical ingredients (APIs). This gap is particularly pressing in process development where API is available in limited quantities yet it is desirable to develop the isolation using continuous equipment which matches the equipment to be used in manufacturing to minimise scale up risks. This paper explores what such a unit must achieve and evaluates a prototype system.
Original languageEnglish
Number of pages18
Publication statusPublished - 13 Oct 2016
EventFiltech - Koelnmesse, Cologne, Germany
Duration: 11 Oct 201613 Oct 2016
http://www.filtech.de/pdfs/filtech2016_conference_programme.pdf

Conference

ConferenceFiltech
Abbreviated titleFiltech 2016
CountryGermany
CityCologne
Period11/10/1613/10/16
Internet address

Keywords

  • continuous filtration
  • optimisation
  • impurity
  • agglomeration
  • drying
  • washing
  • purification

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