Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

Pseudomonas aeruginosa, widely present in the environment, is well known for its ability to cause infection in immune compromised individuals. For example, P. aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF). Here, we describe how Electrochemical Impedance Spectroscopy (EIS) can be used to detect the presence of four different strains of P. aeruginosa. Using a low cost, screen printed carbon electrode significant changes can be seen in impedance data in the presence of P. aeruginosa after 24 hours. Furthermore, through the use of a normalization technique whereby the phase angle of the impedance (a commonly used parameter) is divided by a starting measurement, it is possible to identify differences between a non-mucoid and mucoid strain of P. aeruginosa. Sensors based upon the techniques described here could be used in a number of healthcare scenarios, where there is a need for low cost, real time detection of P. aeruginosa, such as CF.

Conference

ConferenceEngineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
CountryUnited States
CityChicago
Period26/08/1430/08/14

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Electrochemical impedance spectroscopy
Costs
Electrodes
Carbon
Sensors

Keywords

  • biomedical electrodes
  • electrochemical impedance spectroscopy
  • patient diagnosis
  • diagnostic device development
  • screen printed carbon electrode

Cite this

Ward, A. C., Tucker, N. P., & Connolly, P. (2014). Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts. 2757-2760. Paper presented at Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE , Chicago, United States. https://doi.org/10.1109/EMBC.2014.6944194
Ward, Andrew C. ; Tucker, Nicholas P. ; Connolly, Patricia. / Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts. Paper presented at Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE , Chicago, United States.4 p.
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abstract = "Pseudomonas aeruginosa, widely present in the environment, is well known for its ability to cause infection in immune compromised individuals. For example, P. aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF). Here, we describe how Electrochemical Impedance Spectroscopy (EIS) can be used to detect the presence of four different strains of P. aeruginosa. Using a low cost, screen printed carbon electrode significant changes can be seen in impedance data in the presence of P. aeruginosa after 24 hours. Furthermore, through the use of a normalization technique whereby the phase angle of the impedance (a commonly used parameter) is divided by a starting measurement, it is possible to identify differences between a non-mucoid and mucoid strain of P. aeruginosa. Sensors based upon the techniques described here could be used in a number of healthcare scenarios, where there is a need for low cost, real time detection of P. aeruginosa, such as CF.",
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Ward, AC, Tucker, NP & Connolly, P 2014, 'Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts' Paper presented at Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE , Chicago, United States, 26/08/14 - 30/08/14, pp. 2757-2760. https://doi.org/10.1109/EMBC.2014.6944194

Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts. / Ward, Andrew C.; Tucker, Nicholas P.; Connolly, Patricia.

2014. 2757-2760 Paper presented at Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE , Chicago, United States.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts

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AB - Pseudomonas aeruginosa, widely present in the environment, is well known for its ability to cause infection in immune compromised individuals. For example, P. aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF). Here, we describe how Electrochemical Impedance Spectroscopy (EIS) can be used to detect the presence of four different strains of P. aeruginosa. Using a low cost, screen printed carbon electrode significant changes can be seen in impedance data in the presence of P. aeruginosa after 24 hours. Furthermore, through the use of a normalization technique whereby the phase angle of the impedance (a commonly used parameter) is divided by a starting measurement, it is possible to identify differences between a non-mucoid and mucoid strain of P. aeruginosa. Sensors based upon the techniques described here could be used in a number of healthcare scenarios, where there is a need for low cost, real time detection of P. aeruginosa, such as CF.

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KW - electrochemical impedance spectroscopy

KW - patient diagnosis

KW - diagnostic device development

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Ward AC, Tucker NP, Connolly P. Development of a diagnostic device to detect different pseudomonas aeruginosa phenotypes in medically relevant contexts. 2014. Paper presented at Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE , Chicago, United States. https://doi.org/10.1109/EMBC.2014.6944194