Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus

P. Heneghan, P.E. Riches

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The hydraulic permeability, k, of the nucleus pulposus (NP) is crucial, both in withstanding compressive stress and for convective transport of nutrients within the disc. Permeability has previously been determined using biphasic mathematical models, but has not been found by direct permeation experiments, which is the objective of this study. Bovine coccygeal nucleus samples (n=64), φ10mm and thickness 683±49μm (mean±S.D.) were compressed axially to one of λ=1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4 or 0.3, where λ is the stretch ratio. Ringer's solution was permeated through the sample, with an o-ring ensuring axial flow. During stress equilibrium, k was determined and fitted to four permeability-strain equations. Values of k were comparable to those arising from mathematical models, lending confidence to permeability being determined from such models.
Original languageEnglish
Pages (from-to)903-906
Number of pages4
JournalJournal of Biomechanics
Volume41
Issue number4
DOIs
Publication statusPublished - 2008

Keywords

  • intervertebral disc
  • hydraulic permeability
  • compression
  • soft tissue mechanics
  • bioengineering

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