Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus

P. Heneghan, P.E. Riches

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The hydraulic permeability, k, of the nucleus pulposus (NP) is crucial, both in withstanding compressive stress and for convective transport of nutrients within the disc. Permeability has previously been determined using biphasic mathematical models, but has not been found by direct permeation experiments, which is the objective of this study. Bovine coccygeal nucleus samples (n=64), φ10mm and thickness 683±49μm (mean±S.D.) were compressed axially to one of λ=1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4 or 0.3, where λ is the stretch ratio. Ringer's solution was permeated through the sample, with an o-ring ensuring axial flow. During stress equilibrium, k was determined and fitted to four permeability-strain equations. Values of k were comparable to those arising from mathematical models, lending confidence to permeability being determined from such models.
LanguageEnglish
Pages903-906
Number of pages4
JournalJournal of Biomechanics
Volume41
Issue number4
DOIs
Publication statusPublished - 2008

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Permeability
Hydraulics
Mathematical models
Axial flow
Compressive stress
Permeation
Nutrients
Theoretical Models
Experiments
Food
Nucleus Pulposus

Keywords

  • intervertebral disc
  • hydraulic permeability
  • compression
  • soft tissue mechanics
  • bioengineering

Cite this

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Determination of the strain-dependent hydraulic permeability of the compressed bovine nucleus pulposus. / Heneghan, P.; Riches, P.E.

In: Journal of Biomechanics, Vol. 41, No. 4, 2008, p. 903-906.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Heneghan, P.

AU - Riches, P.E.

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AB - The hydraulic permeability, k, of the nucleus pulposus (NP) is crucial, both in withstanding compressive stress and for convective transport of nutrients within the disc. Permeability has previously been determined using biphasic mathematical models, but has not been found by direct permeation experiments, which is the objective of this study. Bovine coccygeal nucleus samples (n=64), φ10mm and thickness 683±49μm (mean±S.D.) were compressed axially to one of λ=1.0, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4 or 0.3, where λ is the stretch ratio. Ringer's solution was permeated through the sample, with an o-ring ensuring axial flow. During stress equilibrium, k was determined and fitted to four permeability-strain equations. Values of k were comparable to those arising from mathematical models, lending confidence to permeability being determined from such models.

KW - intervertebral disc

KW - hydraulic permeability

KW - compression

KW - soft tissue mechanics

KW - bioengineering

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