Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer

Cameron J. Brown, Xiong Wei Ni

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

This work aims to show the viability of applying video imaging techniques to the cooling crystallization of paracetamol in an oscillatory baffled crystallizer for the determination of the metastable zone width and crystal size distribution. From these data, the effects of supersaturation and mixing on metastable zone width and mean particle size are examined. Both sets of data are in good agreement with previous studies in a stirred tank and oscillatory baffled crystallizers. Finally, utilizing the Kubota's interpretation of metastable zone width, we demonstrated that the video imaging techniques are as sensitive to nucleation events as FBRM probes.

LanguageEnglish
Pages2944-2949
Number of pages6
JournalCrystEngComm
Volume14
Issue number8
DOIs
Publication statusPublished - 21 Apr 2012

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Crystallizers
Particle size
Imaging techniques
imaging techniques
Supersaturation
Acetaminophen
Crystallization
Nucleation
supersaturation
Cooling
viability
Crystals
nucleation
crystallization
cooling
probes
crystals

Keywords

  • cooling crystallization
  • paracetamol
  • oscillatory baffled crystallizer
  • crystal size distribution

Cite this

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Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer. / Brown, Cameron J.; Ni, Xiong Wei.

In: CrystEngComm, Vol. 14, No. 8, 21.04.2012, p. 2944-2949.

Research output: Contribution to journalArticle

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