Determination of equilibrium constant of C60 fullerene binding with drug molecules

Andrei A Mosunov, Irina Pashkova, Maria Sidorova, Artem Pronozin, Anastasia Lantushenko, Yuriy I Prylutskyy, John A Parkinson, Maxim P Evstigneev

Research output: Contribution to journalArticle

7 Citations (Scopus)
47 Downloads (Pure)

Abstract

We report a new analytical method that allows the determination of the magnitude of the equilibrium constant of complexation, Kh, of small molecules to C60 fullerene in aqueous solution. The developed method is based on the up-scaled model of C60 fullerene-ligand complexation and contains the full set of equations needed to fit titration datasets arising from different experimental methods (UV-Vis spectroscopy, 1H NMR spectroscopy, diffusion ordered NMR spectroscopy, DLS). The up-scaled model takes into consideration the specificity of C60 fullerene aggregation in aqueous solution and allows the highly dispersed nature of C60 fullerene cluster distribution to be accounted for. It also takes into consideration the complexity of fullerene-ligand dynamic equilibrium in solution, formed by various types of self- and hetero-complexes. These features make the suggested method superior to standard Langmuir-type analysis, the approach used to date for obtaining quantitative information on ligand binding with different nanoparticles.
Original languageEnglish
Pages (from-to)6777-6784
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume19
Issue number9
Early online date10 Feb 2017
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • equilibrium constant
  • C60 fullerene
  • ligands
  • titration datasets
  • NMR spectroscopy
  • Langmuir
  • hetero-complexes
  • ligand binding
  • nanoparticles

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