Determination of equilibrium constant of C60 fullerene binding with drug molecules

Andrei A Mosunov, Irina Pashkova, Maria Sidorova, Artem Pronozin, Anastasia Lantushenko, Yuriy I Prylutskyy, John A Parkinson, Maxim P Evstigneev

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a new analytical method that allows the determination of the magnitude of the equilibrium constant of complexation, Kh, of small molecules to C60 fullerene in aqueous solution. The developed method is based on the up-scaled model of C60 fullerene-ligand complexation and contains the full set of equations needed to fit titration datasets arising from different experimental methods (UV-Vis spectroscopy, 1H NMR spectroscopy, diffusion ordered NMR spectroscopy, DLS). The up-scaled model takes into consideration the specificity of C60 fullerene aggregation in aqueous solution and allows the highly dispersed nature of C60 fullerene cluster distribution to be accounted for. It also takes into consideration the complexity of fullerene-ligand dynamic equilibrium in solution, formed by various types of self- and hetero-complexes. These features make the suggested method superior to standard Langmuir-type analysis, the approach used to date for obtaining quantitative information on ligand binding with different nanoparticles.
LanguageEnglish
Pages6777-6784
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume19
Issue number9
Early online date10 Feb 2017
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Equilibrium constants
fullerenes
drugs
Molecules
Ligands
Complexation
Pharmaceutical Preparations
Nuclear magnetic resonance spectroscopy
molecules
ligands
Fullerenes
spectroscopy
aqueous solutions
Ultraviolet spectroscopy
Titration
nuclear magnetic resonance
Agglomeration
titration
Nanoparticles
fullerene C60

Keywords

  • equilibrium constant
  • C60 fullerene
  • ligands
  • titration datasets
  • NMR spectroscopy
  • Langmuir
  • hetero-complexes
  • ligand binding
  • nanoparticles

Cite this

Mosunov, A. A., Pashkova, I., Sidorova, M., Pronozin, A., Lantushenko, A., Prylutskyy, Y. I., ... Evstigneev, M. P. (2017). Determination of equilibrium constant of C60 fullerene binding with drug molecules. Physical Chemistry Chemical Physics, 19(9), 6777-6784. https://doi.org/10.1039/c6cp07140f
Mosunov, Andrei A ; Pashkova, Irina ; Sidorova, Maria ; Pronozin, Artem ; Lantushenko, Anastasia ; Prylutskyy, Yuriy I ; Parkinson, John A ; Evstigneev, Maxim P. / Determination of equilibrium constant of C60 fullerene binding with drug molecules. In: Physical Chemistry Chemical Physics. 2017 ; Vol. 19, No. 9. pp. 6777-6784.
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Mosunov, AA, Pashkova, I, Sidorova, M, Pronozin, A, Lantushenko, A, Prylutskyy, YI, Parkinson, JA & Evstigneev, MP 2017, 'Determination of equilibrium constant of C60 fullerene binding with drug molecules' Physical Chemistry Chemical Physics, vol. 19, no. 9, pp. 6777-6784. https://doi.org/10.1039/c6cp07140f

Determination of equilibrium constant of C60 fullerene binding with drug molecules. / Mosunov, Andrei A; Pashkova, Irina; Sidorova, Maria; Pronozin, Artem; Lantushenko, Anastasia; Prylutskyy, Yuriy I; Parkinson, John A; Evstigneev, Maxim P.

In: Physical Chemistry Chemical Physics, Vol. 19, No. 9, 01.03.2017, p. 6777-6784.

Research output: Contribution to journalArticle

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T1 - Determination of equilibrium constant of C60 fullerene binding with drug molecules

AU - Mosunov, Andrei A

AU - Pashkova, Irina

AU - Sidorova, Maria

AU - Pronozin, Artem

AU - Lantushenko, Anastasia

AU - Prylutskyy, Yuriy I

AU - Parkinson, John A

AU - Evstigneev, Maxim P

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N2 - We report a new analytical method that allows the determination of the magnitude of the equilibrium constant of complexation, Kh, of small molecules to C60 fullerene in aqueous solution. The developed method is based on the up-scaled model of C60 fullerene-ligand complexation and contains the full set of equations needed to fit titration datasets arising from different experimental methods (UV-Vis spectroscopy, 1H NMR spectroscopy, diffusion ordered NMR spectroscopy, DLS). The up-scaled model takes into consideration the specificity of C60 fullerene aggregation in aqueous solution and allows the highly dispersed nature of C60 fullerene cluster distribution to be accounted for. It also takes into consideration the complexity of fullerene-ligand dynamic equilibrium in solution, formed by various types of self- and hetero-complexes. These features make the suggested method superior to standard Langmuir-type analysis, the approach used to date for obtaining quantitative information on ligand binding with different nanoparticles.

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Mosunov AA, Pashkova I, Sidorova M, Pronozin A, Lantushenko A, Prylutskyy YI et al. Determination of equilibrium constant of C60 fullerene binding with drug molecules. Physical Chemistry Chemical Physics. 2017 Mar 1;19(9):6777-6784. https://doi.org/10.1039/c6cp07140f