Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Samuel Mabbott; Syrena C. Fernandes; Monika Schechinger; Gerard Cote; Karen Faulds; Charles R. Mace; Duncan Graham

doi:10.1039/C9AN01748H

Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Samuel Mabbott, Syrena C. Fernandes, Monika Schechinger, Gerard Cote, Karen Faulds, Charles R. Mace, Duncan Graham

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

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Abstract

Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

Original language	English
Journal	Analyst
Early online date	28 Nov 2019
DOIs	https://doi.org/10.1039/C9AN01748H
Publication status	E-pub ahead of print - 28 Nov 2019

Keywords

myocardial infarction
microfluidics
surface enhanced Raman scattering

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10.1039/C9AN01748H

Mabbott-etal-Analyst-2019-Detection-of-cardiovascular-disease-associated-miR-29a-using-paper-based-microfluidicsAccepted author manuscript, 820 KB

1 Finished

In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy
Graham, D. & Faulds, K.
EPSRC (Engineering and Physical Sciences Research Council)
1/05/14 → 31/10/18
Project: Research

Data for: "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering"
Graham, D. (Creator) & Faulds, K. (Creator), University of Strathclyde, 3 Dec 2019
DOI: 10.15129/608f75c5-0b90-4563-985f-189565a59f07
Dataset

Cite this

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title = "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering",

abstract = "Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.",

keywords = "myocardial infarction, microfluidics, surface enhanced Raman scattering",

author = "Samuel Mabbott and Fernandes, {Syrena C.} and Monika Schechinger and Gerard Cote and Karen Faulds and Mace, {Charles R.} and Duncan Graham",

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month = nov,

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T1 - Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

AU - Mabbott, Samuel

AU - Fernandes, Syrena C.

AU - Schechinger, Monika

AU - Cote, Gerard

AU - Faulds, Karen

AU - Mace, Charles R.

AU - Graham, Duncan

PY - 2019/11/28

Y1 - 2019/11/28

N2 - Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

AB - Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

KW - myocardial infarction

KW - microfluidics

KW - surface enhanced Raman scattering

U2 - 10.1039/C9AN01748H

DO - 10.1039/C9AN01748H

M3 - Article

JO - Analyst

JF - Analyst

SN - 0003-2654

ER -

Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Abstract

Keywords

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In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy

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Data for: "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering"

Cite this