Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Samuel Mabbott; Syrena C. Fernandes; Monika Schechinger; Gerard Cote; Karen Faulds; Charles R. Mace; Duncan Graham

doi:10.1039/C9AN01748H

Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

Samuel Mabbott, Syrena C. Fernandes, Monika Schechinger, Gerard Cote, Karen Faulds, Charles R. Mace, Duncan Graham

Pure And Applied Chemistry

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

Original language	English
Journal	Analyst
Early online date	28 Nov 2019
DOIs	https://doi.org/10.1039/C9AN01748H
Publication status	E-pub ahead of print - 28 Nov 2019

Keywords

myocardial infarction
microfluidics
surface enhanced Raman scattering

Access to Document

10.1039/C9AN01748H

Embargoed Document

Mabbott-etal-Analyst-2019-Detection-of-cardiovascular-disease-associated-miR-29a-using-paper-based-microfluidics
Accepted author manuscript, 820 KB
Embargo ends: 28/11/20

Fingerprint Dive into the research topics of 'Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering'. Together they form a unique fingerprint.

Projects

1 Finished

In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy

Graham, D. & Faulds, K.

EPSRC (Engineering and Physical Sciences Research Council)

1/05/14 → 31/10/18

Project: Research

Datasets

Data for: "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering"

Graham, D. (Creator) & Faulds, K. (Creator), University of Strathclyde, 3 Dec 2019

DOI: 10.15129/608f75c5-0b90-4563-985f-189565a59f07

Dataset

Cite this

Mabbott, S., Fernandes, S. C., Schechinger, M., Cote, G., Faulds, K., Mace, C. R., & Graham, D. (2019). Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering. Analyst. https://doi.org/10.1039/C9AN01748H

@article{9517742c14274182b80b0df17b023af3,

title = "Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering",

abstract = "Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.",

keywords = "myocardial infarction, microfluidics, surface enhanced Raman scattering",

author = "Samuel Mabbott and Fernandes, {Syrena C.} and Monika Schechinger and Gerard Cote and Karen Faulds and Mace, {Charles R.} and Duncan Graham",

year = "2019",

month = nov,

day = "28",

doi = "10.1039/C9AN01748H",

language = "English",

journal = "Analyst",

issn = "0003-2654",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering

AU - Mabbott, Samuel

AU - Fernandes, Syrena C.

AU - Schechinger, Monika

AU - Cote, Gerard

AU - Faulds, Karen

AU - Mace, Charles R.

AU - Graham, Duncan

PY - 2019/11/28

Y1 - 2019/11/28

N2 - Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

AB - Detection of miR-29a-3p, a microRNA associated with myocardial infarction, was achieved at a level of pg/L through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. The union of the paper-based device and the two analysis methods resulted in the production of a sensitive, reproducible and facile, point of care test (POCT), which paves the way for future implementation in the diagnosis of a range of diseases.

KW - myocardial infarction

KW - microfluidics

KW - surface enhanced Raman scattering

U2 - 10.1039/C9AN01748H

DO - 10.1039/C9AN01748H

M3 - Article

JO - Analyst

JF - Analyst

SN - 0003-2654

ER -