Projects per year
Stabilised peptides are now established as potential drug candidates to probe previously intractable molecular targets, such as protein-protein interactions. Herein, we report the design and synthesis of eight short helical peptide analogues of the ubiquitin conjugating enzyme, E2-25K, as potential antagonists of the interaction between E2-25K and the Alzheimer’s Disease (AD) associated ubiquitin mutant Ubb+1. Biochemical evaluation revealed four putative antagonists of the Ubb+1 / E2-25K interaction that reduced incorporation of Ubb+1 into polyubiquitin chains in vitro, validating the potential of this approach as a therapeutic strategy.
|Number of pages||10|
|Early online date||24 Mar 2020|
|Publication status||E-pub ahead of print - 24 Mar 2020|
- Alzheimer disease
Jamieson, C., Percy, J. & Watson, M. E.
1/10/12 → 25/08/16
Project: Research Studentship Case - Internally allocated
Watson, M. E., Scott, D., Jamieson, C., Layfield, R., & Mason, A. M. (2020). Design, synthesis and evaluation of E2-25K derived stapled peptides. Peptide Science, [e24158]. https://doi.org/10.1002/pep2.24158