Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 118-124 |
| Number of pages | 6 |
| Journal | Proceedings of SPIE: The International Society for Optical Engineering |
| Volume | 4253 |
| Issue number | 118 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- drug concentrations
- eye
- paracentesis
- ophthalmology
- contact lens
- drug detection
- optoelectronic
- ocular spectrometer
- cornea
- ocular drug detection
- fluorescence spectroscopy
- biomedical electronics
- biomedical equipment
- biomedical measurement
- chemical sensors
- optical fibres
- optical sensors
- optoelectronic devices
- patient monitoring
- patient treatment
- spectrometers
Cite this
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Design of a novel system for spectroscopy measurements of the aqueous humour. / Miller, J.; Uttamchandani, D.G.
In: Proceedings of SPIE: The International Society for Optical Engineering, Vol. 4253, No. 118, 2001, p. 118-124.Research output: Contribution to journal › Article
TY - JOUR
T1 - Design of a novel system for spectroscopy measurements of the aqueous humour
AU - Miller, J.
AU - Uttamchandani, D.G.
PY - 2001
Y1 - 2001
N2 - The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.
AB - The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.
KW - drug concentrations
KW - eye
KW - paracentesis
KW - ophthalmology
KW - contact lens
KW - drug detection
KW - optoelectronic
KW - ocular spectrometer
KW - cornea
KW - ocular drug detection
KW - fluorescence spectroscopy
KW - biomedical electronics
KW - biomedical equipment
KW - biomedical measurement
KW - chemical sensors
KW - optical fibres
KW - optical sensors
KW - optoelectronic devices
KW - patient monitoring
KW - patient treatment
KW - spectrometers
UR - http://dx.doi.org/10.1117/12.427915
U2 - 10.1117/12.427915
DO - 10.1117/12.427915
M3 - Article
VL - 4253
SP - 118
EP - 124
JO - Proceedings of SPIE
JF - Proceedings of SPIE
SN - 0277-786X
IS - 118
ER -