Design of a novel system for spectroscopy measurements of the aqueous humour

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.
LanguageEnglish
Pages118-124
Number of pages6
JournalProceedings of SPIE: The International Society for Optical Engineering
Volume4253
Issue number118
DOIs
Publication statusPublished - 2001

Fingerprint

contact lenses
Contact lenses
Lens
Spectroscopy
chambers
Lenses
drugs
lenses
spectroscopy
animals
Drugs
Animals
sampling
Pharmaceutical Preparations
Contact
Sampling
Light propagation
Optical design
design optimization
Fused silica

Keywords

  • drug concentrations
  • eye
  • paracentesis
  • ophthalmology
  • contact lens
  • drug detection
  • optoelectronic
  • ocular spectrometer
  • cornea
  • ocular drug detection
  • fluorescence spectroscopy
  • biomedical electronics
  • biomedical equipment
  • biomedical measurement
  • chemical sensors
  • optical fibres
  • optical sensors
  • optoelectronic devices
  • patient monitoring
  • patient treatment
  • spectrometers

Cite this

@article{dfc4a2366e5b44738f7a0b3e811248dc,
title = "Design of a novel system for spectroscopy measurements of the aqueous humour",
abstract = "The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.",
keywords = "drug concentrations, eye, paracentesis, ophthalmology, contact lens, drug detection, optoelectronic, ocular spectrometer, cornea, ocular drug detection, fluorescence spectroscopy, biomedical electronics, biomedical equipment, biomedical measurement, chemical sensors, optical fibres, optical sensors, optoelectronic devices, patient monitoring, patient treatment, spectrometers",
author = "J. Miller and D.G. Uttamchandani",
year = "2001",
doi = "10.1117/12.427915",
language = "English",
volume = "4253",
pages = "118--124",
journal = "Proceedings of SPIE",
issn = "0277-786X",
number = "118",

}

TY - JOUR

T1 - Design of a novel system for spectroscopy measurements of the aqueous humour

AU - Miller, J.

AU - Uttamchandani, D.G.

PY - 2001

Y1 - 2001

N2 - The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.

AB - The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.

KW - drug concentrations

KW - eye

KW - paracentesis

KW - ophthalmology

KW - contact lens

KW - drug detection

KW - optoelectronic

KW - ocular spectrometer

KW - cornea

KW - ocular drug detection

KW - fluorescence spectroscopy

KW - biomedical electronics

KW - biomedical equipment

KW - biomedical measurement

KW - chemical sensors

KW - optical fibres

KW - optical sensors

KW - optoelectronic devices

KW - patient monitoring

KW - patient treatment

KW - spectrometers

UR - http://dx.doi.org/10.1117/12.427915

U2 - 10.1117/12.427915

DO - 10.1117/12.427915

M3 - Article

VL - 4253

SP - 118

EP - 124

JO - Proceedings of SPIE

T2 - Proceedings of SPIE

JF - Proceedings of SPIE

SN - 0277-786X

IS - 118

ER -