Deposition of elastic fibres in a murine cutaneous wound-healing model

L. Shuttleworth, R.A. Black, M. Ferguson, S. Herrick

    Research output: Contribution to journalConference Contribution

    Abstract

    Abstract of paper from TCES (Tissue and Cell Engineering Society) meeting in 2005. The ability of the skin to extend and recoil is mediated by an elastic fibre network comprising elastin molecules deposited on a microfibrillar scaffold. Studies have demonstrated reduced tensile strength in scar tissue following cutaneous wounding, possibly due to decreased amounts of elastic fibres1. The dermal component of artificial skin substitutes also lacks an organised elastic fibre network, which may contribute to excessive contraction and scarring post-grafting. This study aimed to document the temporal and spatial distribution of elastic fibres following incisional and excisional cutaneous wounding in mice.
    LanguageEnglish
    PagesA68-A68
    JournalInternational Journal of Experimental Pathology
    Volume86
    Issue number3
    DOIs
    Publication statusPublished - 2005

    Fingerprint

    Elastic Tissue
    Wound Healing
    Artificial Skin
    Skin
    Cicatrix
    Elastin
    Tensile Strength

    Keywords

    • bioengineering
    • biotechnology
    • skin
    • fibre network
    • elastic fibres

    Cite this

    Shuttleworth, L. ; Black, R.A. ; Ferguson, M. ; Herrick, S. / Deposition of elastic fibres in a murine cutaneous wound-healing model. In: International Journal of Experimental Pathology. 2005 ; Vol. 86, No. 3. pp. A68-A68.
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    Deposition of elastic fibres in a murine cutaneous wound-healing model. / Shuttleworth, L.; Black, R.A.; Ferguson, M.; Herrick, S.

    In: International Journal of Experimental Pathology, Vol. 86, No. 3, 2005, p. A68-A68.

    Research output: Contribution to journalConference Contribution

    TY - JOUR

    T1 - Deposition of elastic fibres in a murine cutaneous wound-healing model

    AU - Shuttleworth, L.

    AU - Black, R.A.

    AU - Ferguson, M.

    AU - Herrick, S.

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    AB - Abstract of paper from TCES (Tissue and Cell Engineering Society) meeting in 2005. The ability of the skin to extend and recoil is mediated by an elastic fibre network comprising elastin molecules deposited on a microfibrillar scaffold. Studies have demonstrated reduced tensile strength in scar tissue following cutaneous wounding, possibly due to decreased amounts of elastic fibres1. The dermal component of artificial skin substitutes also lacks an organised elastic fibre network, which may contribute to excessive contraction and scarring post-grafting. This study aimed to document the temporal and spatial distribution of elastic fibres following incisional and excisional cutaneous wounding in mice.

    KW - bioengineering

    KW - biotechnology

    KW - skin

    KW - fibre network

    KW - elastic fibres

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