Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra)

A L Harvey, K Hayashi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A cardiotoxin-like basic polypeptide from the venom of Naja naja atra is homologous to cardiotoxins from the same venom, but much less toxic. To determine if it acts like the cardiotoxins its depolarizing ability was measured. It was about 10 times less potent than the cardiotoxins. Five amino acids are conserved in the sequences studied, on the exposed second and third loops of the toxin backbone. They may be part of the toxins' interactive site.
Original languageEnglish
Pages (from-to)681-684
Number of pages4
JournalToxicon
Volume25
Issue number6
DOIs
Publication statusPublished - 1987

Keywords

  • aimals
  • chick embryo
  • cobra venoms
  • muscles
  • neuromuscular depolarizing Agents
  • peptides

Fingerprint Dive into the research topics of 'Depolarization of skeletal muscle cells in culture by a cardiotoxin-like basic polypeptide from the venom of the Taiwan cobra (naja naja atra)'. Together they form a unique fingerprint.

  • Cite this