Density measurements through the gel and lamellar phase transitionsof di-tetradecanoyl- and di-hexadecanoyl-phosphatidylcholines: observation of slow relaxation processes and mechanisms of phase transitions

J. W. Jones, L. Lue, A. Saiani, G. J. T. Tiddy

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5 Citations (Scopus)

Abstract

Density measurements on aqueous dispersions of C14: 0/C14:0 and C16:0/C16:0 phosphatidylcholines have been carried out to give information on the mechanism of the phase transitions [main transition: lamellar phase (L-alpha) to gel (P-beta'); pre-transition: gel (P-beta') to second gel phase (L-beta')]. Quite remarkably, for both systems we observe that repeated temperature cycles give different measurements, with a slow relaxation to apparent equilibrium, at least for some of the phases. We also observe that there are marked reductions in lipid density just above the main transition that indicate the spontaneous formation of 'lipid patches'. The density measurements allow the calculation of the relative contributions to the phase transitions from changes in van der Waals energy (Delta U-vdW) and chain configurations (Delta U-Rot). Both contribute to the main transition whilst only changes in the van der Waals energy are involved in the pre-transition.
LanguageEnglish
Pages1465-1481
Number of pages17
JournalLiquid Crystals
Volume32
Issue number11-12
Publication statusPublished - Nov 2005

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Relaxation processes
Phosphatidylcholines
Gels
Phase transitions
gels
Lipids
Dispersions
lipids
Temperature
cycles
energy
configurations

Keywords

  • lipid density
  • phosphatidylcholines
  • lamellar phase transitions

Cite this

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title = "Density measurements through the gel and lamellar phase transitionsof di-tetradecanoyl- and di-hexadecanoyl-phosphatidylcholines: observation of slow relaxation processes and mechanisms of phase transitions",
abstract = "Density measurements on aqueous dispersions of C14: 0/C14:0 and C16:0/C16:0 phosphatidylcholines have been carried out to give information on the mechanism of the phase transitions [main transition: lamellar phase (L-alpha) to gel (P-beta'); pre-transition: gel (P-beta') to second gel phase (L-beta')]. Quite remarkably, for both systems we observe that repeated temperature cycles give different measurements, with a slow relaxation to apparent equilibrium, at least for some of the phases. We also observe that there are marked reductions in lipid density just above the main transition that indicate the spontaneous formation of 'lipid patches'. The density measurements allow the calculation of the relative contributions to the phase transitions from changes in van der Waals energy (Delta U-vdW) and chain configurations (Delta U-Rot). Both contribute to the main transition whilst only changes in the van der Waals energy are involved in the pre-transition.",
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T1 - Density measurements through the gel and lamellar phase transitionsof di-tetradecanoyl- and di-hexadecanoyl-phosphatidylcholines

T2 - Liquid Crystals

AU - Jones, J. W.

AU - Lue, L.

AU - Saiani, A.

AU - Tiddy, G. J. T.

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N2 - Density measurements on aqueous dispersions of C14: 0/C14:0 and C16:0/C16:0 phosphatidylcholines have been carried out to give information on the mechanism of the phase transitions [main transition: lamellar phase (L-alpha) to gel (P-beta'); pre-transition: gel (P-beta') to second gel phase (L-beta')]. Quite remarkably, for both systems we observe that repeated temperature cycles give different measurements, with a slow relaxation to apparent equilibrium, at least for some of the phases. We also observe that there are marked reductions in lipid density just above the main transition that indicate the spontaneous formation of 'lipid patches'. The density measurements allow the calculation of the relative contributions to the phase transitions from changes in van der Waals energy (Delta U-vdW) and chain configurations (Delta U-Rot). Both contribute to the main transition whilst only changes in the van der Waals energy are involved in the pre-transition.

AB - Density measurements on aqueous dispersions of C14: 0/C14:0 and C16:0/C16:0 phosphatidylcholines have been carried out to give information on the mechanism of the phase transitions [main transition: lamellar phase (L-alpha) to gel (P-beta'); pre-transition: gel (P-beta') to second gel phase (L-beta')]. Quite remarkably, for both systems we observe that repeated temperature cycles give different measurements, with a slow relaxation to apparent equilibrium, at least for some of the phases. We also observe that there are marked reductions in lipid density just above the main transition that indicate the spontaneous formation of 'lipid patches'. The density measurements allow the calculation of the relative contributions to the phase transitions from changes in van der Waals energy (Delta U-vdW) and chain configurations (Delta U-Rot). Both contribute to the main transition whilst only changes in the van der Waals energy are involved in the pre-transition.

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KW - phosphatidylcholines

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