Dendrotoxins: how does structure determine function?

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Dendrotoxins are a family of small proteins isolated from mamba (Dendroaspis) snake venoms. The toxins contain 57-60 amino acid residues cross-linked by three disulphide bridges. They are homologous to Kunitz-type serine proteinase inhibitors, such as aprotinin, (BPTI) although they have little anti-proteinase activity. The dendrotoxins block some subtypes of voltage-dependent potassium channels in neurones. Studies with cloned K+ channels indicate that α-dendrotoxin from green mamba Dendroaspis angusticeps blocks Kv1.1, Kv1.2 and Kv1.6 channels in the nanomolar range. Engineered and modified versions of dendrotoxin are being investigated to define the interactive site and account for differences in K+ channel selectivity.

LanguageEnglish
Pages161-182
Number of pages22
JournalJournal of Toxicology - Toxin Reviews
Volume17
Issue number2
DOIs
Publication statusPublished - 1998

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Elapidae
Kv1.2 Potassium Channel
Snake Venoms
Serine Proteinase Inhibitors
Aprotinin
Potassium Channels
Disulfides
Neurons
Proteins
Peptide Hydrolases
dendrotoxin
Amino Acids
Electric potential

Keywords

  • snake venom
  • dendrotoxin
  • mamba venoms

Cite this

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title = "Dendrotoxins: how does structure determine function?",
abstract = "Dendrotoxins are a family of small proteins isolated from mamba (Dendroaspis) snake venoms. The toxins contain 57-60 amino acid residues cross-linked by three disulphide bridges. They are homologous to Kunitz-type serine proteinase inhibitors, such as aprotinin, (BPTI) although they have little anti-proteinase activity. The dendrotoxins block some subtypes of voltage-dependent potassium channels in neurones. Studies with cloned K+ channels indicate that α-dendrotoxin from green mamba Dendroaspis angusticeps blocks Kv1.1, Kv1.2 and Kv1.6 channels in the nanomolar range. Engineered and modified versions of dendrotoxin are being investigated to define the interactive site and account for differences in K+ channel selectivity.",
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}

Dendrotoxins : how does structure determine function? / Dufton, Mark J.; Harvey, Alan L.

In: Journal of Toxicology - Toxin Reviews, Vol. 17, No. 2, 1998, p. 161-182.

Research output: Contribution to journalReview article

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T2 - Journal of Toxicology: Toxin Reviews

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AU - Harvey, Alan L.

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