Dendrotoxin-like effects of noxiustoxin

A L Harvey; D L Marshall; L D Possani

doi:10.1016/0041-0101(92)90528-D

Dendrotoxin-like effects of noxiustoxin

A L Harvey, D L Marshall, L D Possani

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.

Original language	English
Pages (from-to)	1497-1500
Number of pages	4
Journal	Toxicon
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/0041-0101(92)90528-D
Publication status	Published - Nov 1992

Keywords

animals
chick embryo
elapid venoms
iodine radioisotopes
mice
neuromuscular junction
phrenic nerve
potassium channels
rats
respiratory muscles
scorpion venoms
synaptic membranes
synaptosomes

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10.1016/0041-0101(92)90528-D

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title = "Dendrotoxin-like effects of noxiustoxin",

abstract = "Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.",

keywords = "animals, chick embryo, elapid venoms, iodine radioisotopes, mice, neuromuscular junction, phrenic nerve, potassium channels, rats, respiratory muscles, scorpion venoms, synaptic membranes, synaptosomes",

author = "Harvey, {A L} and Marshall, {D L} and Possani, {L D}",

year = "1992",

month = nov,

doi = "10.1016/0041-0101(92)90528-D",

language = "English",

volume = "30",

pages = "1497--1500",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Dendrotoxin-like effects of noxiustoxin

AU - Harvey, A L

AU - Marshall, D L

AU - Possani, L D

PY - 1992/11

Y1 - 1992/11

N2 - Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.

AB - Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.

KW - animals

KW - chick embryo

KW - elapid venoms

KW - iodine radioisotopes

KW - mice

KW - neuromuscular junction

KW - phrenic nerve

KW - potassium channels

KW - rats

KW - respiratory muscles

KW - scorpion venoms

KW - synaptic membranes

KW - synaptosomes

U2 - 10.1016/0041-0101(92)90528-D

DO - 10.1016/0041-0101(92)90528-D

M3 - Article

C2 - 1485346

SN - 0041-0101

VL - 30

SP - 1497

EP - 1500

JO - Toxicon

JF - Toxicon

IS - 11

ER -

Dendrotoxin-like effects of noxiustoxin

Abstract

Keywords

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