Dendrotoxin-like effects of noxiustoxin

A L Harvey, D L Marshall, L D Possani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.
Original languageEnglish
Pages (from-to)1497-1500
Number of pages4
JournalToxicon
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 1992

Keywords

  • animals
  • chick embryo
  • elapid venoms
  • iodine radioisotopes
  • mice
  • neuromuscular junction
  • phrenic nerve
  • potassium channels
  • rats
  • respiratory muscles
  • scorpion venoms
  • synaptic membranes
  • synaptosomes

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