Dendrotoxin-like effects of noxiustoxin

A L Harvey, D L Marshall, L D Possani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.
Original languageEnglish
Pages (from-to)1497-1500
Number of pages4
JournalToxicon
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 1992

Fingerprint

Scorpions
Phrenic Nerve
Neuromuscular Junction
Acetylcholine
Muscle
Rats
Brain
Pharmacology
Membranes
dendrotoxin
noxiustoxin

Keywords

  • animals
  • chick embryo
  • elapid venoms
  • iodine radioisotopes
  • mice
  • neuromuscular junction
  • phrenic nerve
  • potassium channels
  • rats
  • respiratory muscles
  • scorpion venoms
  • synaptic membranes
  • synaptosomes

Cite this

Harvey, A L ; Marshall, D L ; Possani, L D. / Dendrotoxin-like effects of noxiustoxin. In: Toxicon. 1992 ; Vol. 30, No. 11. pp. 1497-1500.
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Harvey, AL, Marshall, DL & Possani, LD 1992, 'Dendrotoxin-like effects of noxiustoxin', Toxicon, vol. 30, no. 11, pp. 1497-1500. https://doi.org/10.1016/0041-0101(92)90528-D

Dendrotoxin-like effects of noxiustoxin. / Harvey, A L; Marshall, D L; Possani, L D.

In: Toxicon, Vol. 30, No. 11, 11.1992, p. 1497-1500.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dendrotoxin-like effects of noxiustoxin

AU - Harvey, A L

AU - Marshall, D L

AU - Possani, L D

PY - 1992/11

Y1 - 1992/11

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AB - Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.

KW - animals

KW - chick embryo

KW - elapid venoms

KW - iodine radioisotopes

KW - mice

KW - neuromuscular junction

KW - phrenic nerve

KW - potassium channels

KW - rats

KW - respiratory muscles

KW - scorpion venoms

KW - synaptic membranes

KW - synaptosomes

U2 - 10.1016/0041-0101(92)90528-D

DO - 10.1016/0041-0101(92)90528-D

M3 - Article

VL - 30

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EP - 1500

JO - Toxicon

JF - Toxicon

SN - 0041-0101

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