Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

G. Robertson; T. Sposito; S. Wray; J. Hardy; T.J. Bushell; M. Zagnoni

Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

G. Robertson, T. Sposito, S. Wray, J. Hardy, T.J. Bushell, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of Publication	San Diego, California
Pages	379-380
Number of pages	2
Publication status	Published - 9 Oct 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTas 2016
Country/Territory	Ireland
City	Dublin
Period	9/10/16 → 13/10/16
Internet address	http://www.microtas2016.org/

Keywords

Alzheimer's disease
calcium imaging
human iPSC
neuronal networks
induced pluripotent stem cells
tau gene
dementia
on-chip platform
microfluidic systems

Cite this

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title = "Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons",

abstract = "Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.",

keywords = "Alzheimer's disease, calcium imaging, human iPSC, neuronal networks, induced pluripotent stem cells, tau gene, dementia, on-chip platform, microfluidic systems",

author = "G. Robertson and T. Sposito and S. Wray and J. Hardy and T.J. Bushell and M. Zagnoni",

year = "2016",

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Robertson, G, Sposito, T, Wray, S, Hardy, J, Bushell, TJ & Zagnoni, M 2016, Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, pp. 379-380, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, 9/10/16.

Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. / Robertson, G.; Sposito, T.; Wray, S.; Hardy, J.; Bushell, T.J.; Zagnoni, M.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, 2016. p. 379-380.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

TY - GEN

T1 - Dementia on a chip

T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences

AU - Robertson, G.

AU - Sposito, T.

AU - Wray, S.

AU - Hardy, J.

AU - Bushell, T.J.

AU - Zagnoni, M.

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AB - Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.

KW - Alzheimer's disease

KW - calcium imaging

KW - human iPSC

KW - neuronal networks

KW - induced pluripotent stem cells

KW - tau gene

KW - dementia

KW - on-chip platform

KW - microfluidic systems

UR - https://cbmsociety.org/conferences/

UR - http://microtas2016.org/

UR - http://www.proceedings.com/33027.html

M3 - Conference contribution book

SN - 9781510834163

SP - 379

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BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)

CY - San Diego, California

Y2 - 9 October 2016 through 13 October 2016

ER -

Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

Abstract

Conference

Keywords

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