Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

G. Robertson, T. Sposito, S. Wray, J. Hardy, T.J. Bushell, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.
LanguageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of PublicationSan Diego, California
Pages379-380
Number of pages2
Publication statusPublished - 9 Oct 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016
http://www.microtas2016.org/

Conference

Conference20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated titleMicroTas 2016
CountryIreland
CityDublin
Period9/10/1613/10/16
Internet address

Fingerprint

Stem cells
Microfluidics
Neurons
Dementia
Genes
Induced Pluripotent Stem Cells
Mutation
Monitoring
Communication
Coculture Techniques
Astrocytes

Keywords

  • Alzheimer's disease
  • calcium imaging
  • human iPSC
  • neuronal networks
  • induced pluripotent stem cells
  • tau gene
  • dementia
  • on-chip platform
  • microfluidic systems

Cite this

Robertson, G., Sposito, T., Wray, S., Hardy, J., Bushell, T. J., & Zagnoni, M. (2016). Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 379-380). San Diego, California.
Robertson, G. ; Sposito, T. ; Wray, S. ; Hardy, J. ; Bushell, T.J. ; Zagnoni, M. / Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, 2016. pp. 379-380
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Robertson, G, Sposito, T, Wray, S, Hardy, J, Bushell, TJ & Zagnoni, M 2016, Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, pp. 379-380, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, 9/10/16.

Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. / Robertson, G.; Sposito, T.; Wray, S.; Hardy, J.; Bushell, T.J.; Zagnoni, M.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, 2016. p. 379-380.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Robertson G, Sposito T, Wray S, Hardy J, Bushell TJ, Zagnoni M. Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California. 2016. p. 379-380