Abstract
Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) |
| Place of Publication | San Diego, California |
| Pages | 379-380 |
| Number of pages | 2 |
| Publication status | Published - 9 Oct 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/ |
Conference
| Conference | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|---|
| Abbreviated title | MicroTas 2016 |
| Country | Ireland |
| City | Dublin |
| Period | 9/10/16 → 13/10/16 |
| Internet address |
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Keywords
- Alzheimer's disease
- calcium imaging
- human iPSC
- neuronal networks
- induced pluripotent stem cells
- tau gene
- dementia
- on-chip platform
- microfluidic systems
Cite this
Robertson, G., Sposito, T., Wray, S., Hardy, J., Bushell, T. J., & Zagnoni, M. (2016). Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) (pp. 379-380). San Diego, California.