Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

G. Robertson; T. Sposito; S. Wray; J. Hardy; T.J. Bushell; M. Zagnoni

Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

G. Robertson, T. Sposito, S. Wray, J. Hardy, T.J. Bushell, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.

Original language	English
Title of host publication	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016)
Place of Publication	San Diego, California
Pages	379-380
Number of pages	2
Publication status	Published - 9 Oct 2016
Event	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Convention Center Dublin, Dublin, Ireland Duration: 9 Oct 2016 → 13 Oct 2016 http://www.microtas2016.org/

Conference

Conference	20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Abbreviated title	MicroTas 2016
Country	Ireland
City	Dublin
Period	9/10/16 → 13/10/16
Internet address	http://www.microtas2016.org/

Keywords

Alzheimer's disease
calcium imaging
human iPSC
neuronal networks
induced pluripotent stem cells
tau gene
dementia
on-chip platform
microfluidic systems

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title = "Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons",

abstract = "Using patient derived induced pluripotent stem cells (iPSCs) with a genetic mutation in the tau gene (MAPT) we can model specific aspects of dementia in an on-chip platform. We have developed a microfluidic system to characterise synaptic communication between healthy and mutation-carrying networked neurons where synaptic maturity has been accelerated using human astrocyte co-cultures.",

keywords = "Alzheimer's disease, calcium imaging, human iPSC, neuronal networks, induced pluripotent stem cells, tau gene, dementia, on-chip platform, microfluidic systems",

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year = "2016",

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Robertson, G, Sposito, T, Wray, S, Hardy, J, Bushell, TJ & Zagnoni, M 2016, Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, pp. 379-380, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, 9/10/16.

Dementia on a chip : monitoring synaptic dysfunction of patient derived human neurons. / Robertson, G.; Sposito, T.; Wray, S.; Hardy, J.; Bushell, T.J.; Zagnoni, M.

20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, 2016. p. 379-380.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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