Dehydroabietylamine-based cellulose nanofibril films: a new class of sustainable biomaterials for highly efficient, broad-spectrum antimicrobial effects

Ghada Hassan, Nina Forsman, Xing Wan, Leena Keurulainen, Luis M. Bimbo, Leena-Sisko Johansson, Nina Sipari, Jari Yli-Kauhaluoma, Ralf Zimmernann, Susanne Stehl, Carsten Werner, Per E. J. Saris, Monika Osterberg, Vania M. Moreira

Research output: Contribution to journalArticle

Abstract

The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against gram positive and negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 105 colony forming units (CFU)/mL bacterial suspensions, after 24 hours of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of eco-friendly biomaterial that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.
LanguageEnglish
Pages5002-5009
Number of pages8
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number5
Early online date4 Feb 2019
DOIs
Publication statusPublished - 4 Mar 2019

Fingerprint

Cellulose films
Biocompatible Materials
Biomaterials
Cellulose
cellulose
Silver
silver
Methicillin Resistance
Methicillin
Functional materials
Poisons
Chemical modification
Gram-Positive Bacteria
buffering
Gram-Negative Bacteria
Biocompatibility
Microorganisms
Health Care Costs
Toxicity
dehydroabietylamine

Keywords

  • nanocellulose
  • dehydroabietylamine
  • antimicrobial
  • drug resistant
  • silver
  • biomaterials

Cite this

Hassan, Ghada ; Forsman, Nina ; Wan, Xing ; Keurulainen, Leena ; Bimbo, Luis M. ; Johansson, Leena-Sisko ; Sipari, Nina ; Yli-Kauhaluoma, Jari ; Zimmernann, Ralf ; Stehl, Susanne ; Werner, Carsten ; Saris, Per E. J. ; Osterberg, Monika ; Moreira, Vania M. / Dehydroabietylamine-based cellulose nanofibril films : a new class of sustainable biomaterials for highly efficient, broad-spectrum antimicrobial effects. In: ACS Sustainable Chemistry and Engineering. 2019 ; Vol. 7, No. 5. pp. 5002-5009.
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Hassan, G, Forsman, N, Wan, X, Keurulainen, L, Bimbo, LM, Johansson, L-S, Sipari, N, Yli-Kauhaluoma, J, Zimmernann, R, Stehl, S, Werner, C, Saris, PEJ, Osterberg, M & Moreira, VM 2019, 'Dehydroabietylamine-based cellulose nanofibril films: a new class of sustainable biomaterials for highly efficient, broad-spectrum antimicrobial effects' ACS Sustainable Chemistry and Engineering, vol. 7, no. 5, pp. 5002-5009. https://doi.org/10.1021/acssuschemeng.8b05658

Dehydroabietylamine-based cellulose nanofibril films : a new class of sustainable biomaterials for highly efficient, broad-spectrum antimicrobial effects. / Hassan, Ghada; Forsman, Nina; Wan, Xing; Keurulainen, Leena; Bimbo, Luis M.; Johansson, Leena-Sisko; Sipari, Nina; Yli-Kauhaluoma, Jari; Zimmernann, Ralf; Stehl, Susanne; Werner, Carsten; Saris, Per E. J.; Osterberg, Monika; Moreira, Vania M.

In: ACS Sustainable Chemistry and Engineering, Vol. 7, No. 5, 04.03.2019, p. 5002-5009.

Research output: Contribution to journalArticle

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T2 - ACS Sustainable Chemistry and Engineering

AU - Hassan, Ghada

AU - Forsman, Nina

AU - Wan, Xing

AU - Keurulainen, Leena

AU - Bimbo, Luis M.

AU - Johansson, Leena-Sisko

AU - Sipari, Nina

AU - Yli-Kauhaluoma, Jari

AU - Zimmernann, Ralf

AU - Stehl, Susanne

AU - Werner, Carsten

AU - Saris, Per E. J.

AU - Osterberg, Monika

AU - Moreira, Vania M.

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KW - nanocellulose

KW - dehydroabietylamine

KW - antimicrobial

KW - drug resistant

KW - silver

KW - biomaterials

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