TY - JOUR
T1 - Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum
AU - Cecchini, Mario Amore
AU - Yassuda, Monica Sanches
AU - Squarzoni, Paula
AU - Coutinho, Artur Martins
AU - de Paula Faria, Daniele
AU - de Souza Duran, Fábio Luiz
AU - Antunes da Costa, Naomi
AU - de Gobbi Porto, Fábio Henrique
AU - Nitrini, Ricardo
AU - Vicente Forlenza, Orestes
AU - Dozzi Brucki, Sonia Maria
AU - Buchpiguel, Carlos Alberto
AU - Parra Rodriguez, Mario
AU - Busatto, Geraldo
PY - 2021/5/6
Y1 - 2021/5/6
N2 - The short-term memory binding (STMB) test involves the ability to hold in memory the integration between surface features, such as shapes and colours. The STMB test has been used to detect Alzheimer’s disease (AD) at different stages, from preclinical to dementia, showing promising results. The objective of the present study was to verify whether the STMB test could differentiate patients with distinct biomarker profiles in the AD continuum. The sample comprised 18 cognitively unimpaired (CU) participants, 30 mild cognitive impairment (MCI) and 23 AD patients. All participants underwent positron emission tomography (PET) with Pittsburgh compound-B labelled with carbon-11 ([11C]PIB) assessing amyloid beta (Aβ) aggregation (A) and 18fluorine-fluorodeoxyglucose ([18F]FDG)-PET assessing neurodegeneration (N) (A-N- [n = 35]); A+N- [n = 11]; A+N+ [n = 19]). Participants who were negative and positive for amyloid deposition were compared in the absence (A-N- vs. A+N-) of neurodegeneration. When compared with the RAVLT and SKT memory tests, the STMB was the only cognitive task that differentiated these groups, predicting the group outcome in logistic regression analyses. The STMB test showed to be sensitive to the signs of AD pathology and may represent a cognitive marker within the AD continuum.
AB - The short-term memory binding (STMB) test involves the ability to hold in memory the integration between surface features, such as shapes and colours. The STMB test has been used to detect Alzheimer’s disease (AD) at different stages, from preclinical to dementia, showing promising results. The objective of the present study was to verify whether the STMB test could differentiate patients with distinct biomarker profiles in the AD continuum. The sample comprised 18 cognitively unimpaired (CU) participants, 30 mild cognitive impairment (MCI) and 23 AD patients. All participants underwent positron emission tomography (PET) with Pittsburgh compound-B labelled with carbon-11 ([11C]PIB) assessing amyloid beta (Aβ) aggregation (A) and 18fluorine-fluorodeoxyglucose ([18F]FDG)-PET assessing neurodegeneration (N) (A-N- [n = 35]); A+N- [n = 11]; A+N+ [n = 19]). Participants who were negative and positive for amyloid deposition were compared in the absence (A-N- vs. A+N-) of neurodegeneration. When compared with the RAVLT and SKT memory tests, the STMB was the only cognitive task that differentiated these groups, predicting the group outcome in logistic regression analyses. The STMB test showed to be sensitive to the signs of AD pathology and may represent a cognitive marker within the AD continuum.
KW - Alzheimer disease
KW - short-term memory binding
KW - PET
KW - biomarkers
KW - amyloid
KW - mild cognitive impairment
KW - Short Term Memory Binding Test
KW - neurodegeneration
UR - https://www.sciencedirect.com/journal/brain-and-cognition
M3 - Article
JO - Brain and Cognition
JF - Brain and Cognition
SN - 0278-2626
ER -