Cytotoxicity of isolated compounds from the extracts of Struchium sparganophora (Linn) Ktze asteraceae

L.S. Kasim, Valerie Ferro, OA Odukoya, GE Ukpo, Veronique Seidel, Alexander Gray, Roger Waigh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Chemical investigation of the leaves of Struchium sparganophora by the application of VLC, CL and PTLC resulted in isolation of three compounds. The cytotoxicity activity of these compounds on malignant human cultured cells was examined. Vernodalin showed a significant cytotoxic activity on the melanoma and ovarian cancer cell lines (P<0.05) while the conjugated 3 methyl, 2, 6 hexacosedienol and luteolin caused cell death after 48h reculture without them. These compounds portend an effective remedy if subjected to structural modification to enhance its’ efficacy and the dietary importance of this plant as a culinary herb in west Africa countries is evidence by the presence of these antitumour compounds in this plant.
LanguageEnglish
Pages475-478
Number of pages4
JournalPakistan journal of pharmaceutical sciences
Volume24
Issue number4
Publication statusPublished - Oct 2011

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Asteraceae
Luteolin
Western Africa
Ovarian Neoplasms
Cultured Cells
Melanoma
Cell Death
Cell Line
vernodalin

Keywords

  • cytotoxicity
  • struchium sparganophora
  • pharmacology
  • luteolin
  • vernodalin

Cite this

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abstract = "Chemical investigation of the leaves of Struchium sparganophora by the application of VLC, CL and PTLC resulted in isolation of three compounds. The cytotoxicity activity of these compounds on malignant human cultured cells was examined. Vernodalin showed a significant cytotoxic activity on the melanoma and ovarian cancer cell lines (P<0.05) while the conjugated 3 methyl, 2, 6 hexacosedienol and luteolin caused cell death after 48h reculture without them. These compounds portend an effective remedy if subjected to structural modification to enhance its’ efficacy and the dietary importance of this plant as a culinary herb in west Africa countries is evidence by the presence of these antitumour compounds in this plant.",
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Cytotoxicity of isolated compounds from the extracts of Struchium sparganophora (Linn) Ktze asteraceae. / Kasim, L.S.; Ferro, Valerie; Odukoya, OA; Ukpo, GE; Seidel, Veronique; Gray, Alexander; Waigh, Roger.

In: Pakistan journal of pharmaceutical sciences, Vol. 24, No. 4, 10.2011, p. 475-478.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytotoxicity of isolated compounds from the extracts of Struchium sparganophora (Linn) Ktze asteraceae

AU - Kasim, L.S.

AU - Ferro, Valerie

AU - Odukoya, OA

AU - Ukpo, GE

AU - Seidel, Veronique

AU - Gray, Alexander

AU - Waigh, Roger

PY - 2011/10

Y1 - 2011/10

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AB - Chemical investigation of the leaves of Struchium sparganophora by the application of VLC, CL and PTLC resulted in isolation of three compounds. The cytotoxicity activity of these compounds on malignant human cultured cells was examined. Vernodalin showed a significant cytotoxic activity on the melanoma and ovarian cancer cell lines (P<0.05) while the conjugated 3 methyl, 2, 6 hexacosedienol and luteolin caused cell death after 48h reculture without them. These compounds portend an effective remedy if subjected to structural modification to enhance its’ efficacy and the dietary importance of this plant as a culinary herb in west Africa countries is evidence by the presence of these antitumour compounds in this plant.

KW - cytotoxicity

KW - struchium sparganophora

KW - pharmacology

KW - luteolin

KW - vernodalin

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