Cytotoxic diterpenes from scoparia dulcis

M. Ahsan, S.N. Islam, A.I. Gray, W.H. Stimson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.
LanguageEnglish
Pages958-961
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number7
DOIs
Publication statusPublished - Jul 2003

Fingerprint

Scoparia
Diterpenes
Cytotoxicity
Complex Mixtures
Stomach Neoplasms
Cells
Nuclear magnetic resonance
Antennas
Cell Line
scopadulciol

Keywords

  • beta-glucuronidase inhibitor
  • cell-lines
  • acid-a
  • triterpenoids

Cite this

Ahsan, M. ; Islam, S.N. ; Gray, A.I. ; Stimson, W.H. / Cytotoxic diterpenes from scoparia dulcis. In: Journal of Natural Products. 2003 ; Vol. 66, No. 7. pp. 958-961.
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Cytotoxic diterpenes from scoparia dulcis. / Ahsan, M.; Islam, S.N.; Gray, A.I.; Stimson, W.H.

In: Journal of Natural Products, Vol. 66, No. 7, 07.2003, p. 958-961.

Research output: Contribution to journalArticle

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KW - cell-lines

KW - acid-a

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