Cytotoxic diterpenes from scoparia dulcis

M. Ahsan; S.N. Islam; A.I. Gray; W.H. Stimson

doi:10.1021/np020356j

Cytotoxic diterpenes from scoparia dulcis

M. Ahsan, S.N. Islam, A.I. Gray, W.H. Stimson

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.

Original language	English
Pages (from-to)	958-961
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	7
DOIs	https://doi.org/10.1021/np020356j
Publication status	Published - Jul 2003

Keywords

beta-glucuronidase inhibitor
cell-lines
acid-a
triterpenoids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np020356j

Cite this

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title = "Cytotoxic diterpenes from scoparia dulcis",

abstract = "Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.",

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doi = "10.1021/np020356j",

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journal = "Journal of Natural Products",

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T1 - Cytotoxic diterpenes from scoparia dulcis

AU - Ahsan, M.

AU - Islam, S.N.

AU - Gray, A.I.

AU - Stimson, W.H.

PY - 2003/7

Y1 - 2003/7

N2 - Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.

AB - Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.

KW - beta-glucuronidase inhibitor

KW - cell-lines

KW - acid-a

KW - triterpenoids

UR - http://dx.doi.org/10.1021/np020356j

U2 - 10.1021/np020356j

DO - 10.1021/np020356j

M3 - Article

SN - 0163-3864

VL - 66

SP - 958

EP - 961

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

Cytotoxic diterpenes from scoparia dulcis

Abstract

Keywords

UN SDGs

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