Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase ß in human endothelial cells

E. Ritchie, M. Saka, C. MacKenzie, R.M. Drummond, C. Wheeler-Jones, T. Kanke, R.J. Plevin

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62 Citations (Scopus)


Up-regulation of proteinase-activated receptor-2 (PAR2) is a factor in a number of disease states and we have therefore examined the signalling pathways involved in the expression of the receptor.
Original languageEnglish
Pages (from-to)1044-1054
Number of pages10
JournalBritish Journal of Pharmacology
Publication statusPublished - 2007


  • adenovirus
  • 2-furoyl(2f)-LIGKV-OH
  • human umbilical vein
  • endothelial cells
  • inhibitory kappa
  • B kinase
  • nuclear factor
  • kappa B
  • proteinase-activated receptor

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