Cystic fibrosis patient monitor

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

8 Downloads (Pure)

Abstract

Cystic Fibrosis (CF) is a genetic disease which affects the body’s ability to regulate chloride movement across epithelial cells, leading to life-limiting conditions such as chronic airway infection and pancreatic disease. Treatments for CF are emerging which aim to correct and enhance the underlying CFTR protein dysfunction which causes the disease. Sweat Cl- concentration is a key biomarker in gauging the efficacy of such treatments. To be able to measure Clin sweat non-invasively in real time, we are developing a wearable, chloride-sensitive patch. This study shows that pHEMA-adapted electrodes can be used to successfully detect clinically relevant changes in Cl- concentration. Studies carried out with an in vitro cell suggest that the electrodes could be used as part of a wearable device capable of monitoring transdermal chloride concentrations. Such a device would play a vital role in monitoring the impact emerging CF treatments have on CFTR functionality, the underlying cause of CF.

Original languageEnglish
Title of host publicationBioMedEng19 Conference Proceedings
Place of PublicationLondon
Pages78
Number of pages1
ISBN (Electronic)9781999646523
Publication statusPublished - 5 Sep 2019
EventBioMedEng19 - London, United Kingdom
Duration: 5 Sep 20196 Sep 2019
https://www.biomedeng19.com/

Conference

ConferenceBioMedEng19
CountryUnited Kingdom
CityLondon
Period5/09/196/09/19
Internet address

Keywords

  • Cystic Fibrosis
  • CF
  • CFTR protein dysfunction
  • pHEMA-adapted electrodes

Fingerprint Dive into the research topics of 'Cystic fibrosis patient monitor'. Together they form a unique fingerprint.

Cite this