Cystic fibrosis patient monitor

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Cystic Fibrosis (CF) is a genetic disease which affects the body’s ability to regulate chloride movement across epithelial cells, leading to life-limiting conditions such as chronic airway infection and pancreatic disease. Treatments for CF are emerging which aim to correct and enhance the underlying CFTR protein dysfunction which causes the disease. Sweat Cl- concentration is a key biomarker in gauging the efficacy of such treatments. To be able to measure Clin sweat non-invasively in real time, we are developing a wearable, chloride-sensitive patch. This study shows that pHEMA-adapted electrodes can be used to successfully detect clinically relevant changes in Cl- concentration. Studies carried out with an in vitro cell suggest that the electrodes could be used as part of a wearable device capable of monitoring transdermal chloride concentrations. Such a device would play a vital role in monitoring the impact emerging CF treatments have on CFTR functionality, the underlying cause of CF.

LanguageEnglish
Title of host publicationBioMedEng19 Conference Proceedings
Place of PublicationLondon
Pages78
Number of pages1
ISBN (Electronic)9781999646523
Publication statusPublished - 5 Sep 2019
EventBioMedEng19 - London, United Kingdom
Duration: 5 Sep 20196 Sep 2019
https://www.biomedeng19.com/

Conference

ConferenceBioMedEng19
CountryUnited Kingdom
CityLondon
Period5/09/196/09/19
Internet address

Fingerprint

Electrodes
Gaging
Monitoring
Biomarkers
Proteins
Epithelial Cells

Keywords

  • Cystic Fibrosis
  • CF
  • CFTR protein dysfunction
  • pHEMA-adapted electrodes

Cite this

Donnelly, S., Ward, A. C., MacGregor, G., & Connolly, P. (2019). Cystic fibrosis patient monitor. In BioMedEng19 Conference Proceedings (pp. 78). London.
Donnelly, S. ; Ward, A.C. ; MacGregor, G. ; Connolly, P. / Cystic fibrosis patient monitor. BioMedEng19 Conference Proceedings. London, 2019. pp. 78
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Donnelly, S, Ward, AC, MacGregor, G & Connolly, P 2019, Cystic fibrosis patient monitor. in BioMedEng19 Conference Proceedings. London, pp. 78, BioMedEng19, London, United Kingdom, 5/09/19.

Cystic fibrosis patient monitor. / Donnelly, S.; Ward, A.C.; MacGregor, G.; Connolly, P.

BioMedEng19 Conference Proceedings. London, 2019. p. 78.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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T1 - Cystic fibrosis patient monitor

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AB - Cystic Fibrosis (CF) is a genetic disease which affects the body’s ability to regulate chloride movement across epithelial cells, leading to life-limiting conditions such as chronic airway infection and pancreatic disease. Treatments for CF are emerging which aim to correct and enhance the underlying CFTR protein dysfunction which causes the disease. Sweat Cl- concentration is a key biomarker in gauging the efficacy of such treatments. To be able to measure Clin sweat non-invasively in real time, we are developing a wearable, chloride-sensitive patch. This study shows that pHEMA-adapted electrodes can be used to successfully detect clinically relevant changes in Cl- concentration. Studies carried out with an in vitro cell suggest that the electrodes could be used as part of a wearable device capable of monitoring transdermal chloride concentrations. Such a device would play a vital role in monitoring the impact emerging CF treatments have on CFTR functionality, the underlying cause of CF.

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Donnelly S, Ward AC, MacGregor G, Connolly P. Cystic fibrosis patient monitor. In BioMedEng19 Conference Proceedings. London. 2019. p. 78