TY - JOUR
T1 - Cyclodextrin-based dermatological formulations
T2 - dermopharmaceutical and cosmetic applications
AU - Ferreira, Laura
AU - Mascarenhas-Melo, Filipa
AU - Rabaça, Sofia
AU - Mathur, Ankita
AU - Sharma, Ankur
AU - Giram, Prabhanjan S.
AU - Pawar, Kiran D.
AU - Rahdar, Abbas
AU - Raza, Faisal
AU - Veiga, Francisco
AU - Gava Mazzola, Priscila
AU - Paiva-Santos, Ana Cláudia
PY - 2023/1/31
Y1 - 2023/1/31
N2 - The progress in new delivery systems for active ingredients has boosted the dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin permeation capabilities. Cyclodextrins (CDs) are cyclic oligosaccharides able to form host-guest inclusion complexes with guest active molecules, resulting in improved physicochemical properties of such molecules. The incorporation of CDs in dermopharmaceutical and cosmetics formulations has received much attention since the late 1970 s by enhancing modulation of the passage through the skin and vectorization into the target site while simultaneously offering a biocompatible delivery system. This paper features the advantages of CDs in dermopharmaceutical and cosmetic applications, such as the improvement of the apparent solubility and the stability of the active ingredients, the possibility of masking unpleasant odors, among others that are be described, emphasizing that these versatile skin active ingredient carriers are strongly promising both in the treatment of skin diseases and in the improvement of cosmetic formulations.
AB - The progress in new delivery systems for active ingredients has boosted the dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin permeation capabilities. Cyclodextrins (CDs) are cyclic oligosaccharides able to form host-guest inclusion complexes with guest active molecules, resulting in improved physicochemical properties of such molecules. The incorporation of CDs in dermopharmaceutical and cosmetics formulations has received much attention since the late 1970 s by enhancing modulation of the passage through the skin and vectorization into the target site while simultaneously offering a biocompatible delivery system. This paper features the advantages of CDs in dermopharmaceutical and cosmetic applications, such as the improvement of the apparent solubility and the stability of the active ingredients, the possibility of masking unpleasant odors, among others that are be described, emphasizing that these versatile skin active ingredient carriers are strongly promising both in the treatment of skin diseases and in the improvement of cosmetic formulations.
KW - active ingredeint
KW - cyclodextrin
KW - cosmetic
KW - dermopharmaceutical
KW - skin
U2 - 10.1016/j.colsurfb.2022.113012
DO - 10.1016/j.colsurfb.2022.113012
M3 - Review article
SN - 0927-7765
VL - 221
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 113012
ER -