Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

A. Grzelczyk, P. Rytczak, A. Okruszek, M. Koziolkiewicz, N. Pyne, S. Pyne

Research output: Contribution to journalConference Contribution

Abstract

Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.
Original languageEnglish
Pages (from-to)S32
Number of pages1
JournalChemistry and Physics of Lipids
Volume164
Issue numberSupplement
DOIs
Publication statusPublished - Aug 2011
Event52nd International Conference on the Bioscience of Lipids - Warsaw, Poland
Duration: 30 Aug 20113 Sep 2011

Keywords

  • bioactive lipid mediators
  • tumor cell
  • LPA receptors

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