Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

A. Grzelczyk; P. Rytczak; A. Okruszek; M. Koziolkiewicz; N. Pyne; S. Pyne

doi:10.1016/j.chemphyslip.2011.05.102

Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

A. Grzelczyk, P. Rytczak, A. Okruszek, M. Koziolkiewicz, N. Pyne, S. Pyne

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

Abstract

Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.

Original language	English
Pages (from-to)	S32
Number of pages	1
Journal	Chemistry and Physics of Lipids
Volume	164
Issue number	Supplement
DOIs	https://doi.org/10.1016/j.chemphyslip.2011.05.102
Publication status	Published - Aug 2011
Event	52nd International Conference on the Bioscience of Lipids - Warsaw, Poland Duration: 30 Aug 2011 → 3 Sept 2011

Keywords

bioactive lipid mediators
tumor cell
LPA receptors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chemphyslip.2011.05.102

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title = "Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors",

abstract = "Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.",

keywords = "bioactive lipid mediators, tumor cell, LPA receptors",

author = "A. Grzelczyk and P. Rytczak and A. Okruszek and M. Koziolkiewicz and N. Pyne and S. Pyne",

year = "2011",

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doi = "10.1016/j.chemphyslip.2011.05.102",

language = "English",

volume = "164",

pages = "S32",

journal = "Chemistry and Physics of Lipids",

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TY - JOUR

T1 - Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

AU - Grzelczyk, A.

AU - Rytczak, P.

AU - Okruszek, A.

AU - Koziolkiewicz, M.

AU - Pyne, N.

AU - Pyne, S.

PY - 2011/8

Y1 - 2011/8

N2 - Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.

AB - Cyclic phosphatidic acid (1-acyl-sn-glycerol-2,3 cyclic phosphate, cPA) and lysophosphatidic acid (LPA) are bioactive lipid mediators belonging to the small glycerophospholipids. Recent studies have shown that these compounds possess contrasting biological activities: LPA induces tumor cell proliferation and motility, while cPA suppresses metastasis and invasion of cancer cells. There are known at least eight LPA receptors involved in LPA signaling, however selective receptors of cPA are still unknown.

KW - bioactive lipid mediators

KW - tumor cell

KW - LPA receptors

U2 - 10.1016/j.chemphyslip.2011.05.102

DO - 10.1016/j.chemphyslip.2011.05.102

M3 - Conference Contribution

SN - 0009-3084

VL - 164

SP - S32

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

IS - Supplement

T2 - 52nd International Conference on the Bioscience of Lipids

Y2 - 30 August 2011 through 3 September 2011

ER -

Cyclic phosphatidic acid and its analogues can regulate ERK1/2 activity via LPA receptors

Abstract

Keywords

UN SDGs

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