Cyclic AMP signalling in pancreatic islets

Research output: Contribution to journalLiterature review

58 Citations (Scopus)

Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.
LanguageEnglish
Pages281-304
Number of pages23
JournalAdvances in Experimental Medicine and Biology
Volume654
DOIs
Publication statusPublished - 2010

Fingerprint

Adenosine Monophosphate
Islets of Langerhans
Cyclic AMP
Insulin-Secreting Cells
Glucose
Insulin
Incretins
Glucagon-Like Peptide 1
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Adenylyl Cyclases
Hormones
Calcium
Cell Differentiation
Cell Survival
Enzymes
Growth

Keywords

  • cyclic amp
  • adenylyl cyclase
  • phosphodiesterase
  • insulin secretion
  • protein kinase
  • pancreas

Cite this

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title = "Cyclic AMP signalling in pancreatic islets",
abstract = "Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.",
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Cyclic AMP signalling in pancreatic islets. / Furman, Brian L.; Ong, W.K.; Pyne, Nigel J.

In: Advances in Experimental Medicine and Biology, Vol. 654, 2010, p. 281-304.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Cyclic AMP signalling in pancreatic islets

AU - Furman, Brian L.

AU - Ong, W.K.

AU - Pyne, Nigel J.

PY - 2010

Y1 - 2010

N2 - Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

AB - Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell.

KW - cyclic amp

KW - adenylyl cyclase

KW - phosphodiesterase

KW - insulin secretion

KW - protein kinase

KW - pancreas

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