Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array

Zhen Qiu, Roderick Habeshaw, Dave Lines, Sandy Cochran

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Abstract

Ultrasound-mediated targeted drug delivery (UmTDD) has the potential to enhance the chemotherapeutic treatment of cancer by allowing increased drug doses preferentially at the location of the tumor. Although gaining increasing interest over the past few years, research into UmTDD system configurations has been hindered by the lack of experimental driving systems and ultrasound devices. In the work reported here, a piezocrystal composite geodesic phased array with 96 elements was connected to commercial programmable multi-channel electronics based on NI-PXIe / FlexRIO-FPGA hardware. The system was modified to provide appropriate ultrasound intensities through power and heat dissipation strategies. Auto-focusing was applied by phase aberration correction. Preliminary results using cross-correlation are presented to demonstrate its applicability. The pressure intensity at the focus of the array was increased four times while the intensity of side lobes were below -12 dB.
LanguageEnglish
Title of host publication2014 IEEE International Ultrasonics Symposium
Place of PublicationPiscataway
PublisherIEEE
Pages811-814
Number of pages4
ISBN (Print)9781479970506
DOIs
Publication statusPublished - 3 Sep 2014
EventIEEE 2014 International Ultrasonics Symposium - Hilton, Chicago, United Kingdom
Duration: 3 Sep 20146 Sep 2014

Conference

ConferenceIEEE 2014 International Ultrasonics Symposium
CountryUnited Kingdom
CityChicago
Period3/09/146/09/14

Fingerprint

Electronic equipment
Ultrasonics
Drug Delivery Systems
Pharmaceutical Preparations
Neoplasms
Hot Temperature
Pressure
Equipment and Supplies
Aberrations
Heat losses
Research
Field programmable gate arrays (FPGA)
Tumors
Energy dissipation
Hardware
Targeted drug delivery
Composite materials
Therapeutics

Keywords

  • modular electronics
  • geodesic array
  • piezocrystal
  • ultrasound mediated targeted drug delivery
  • biomedical electronics
  • biomedical ultrasonics
  • cancer
  • drug delivery systems
  • piezoelectric materials
  • tumours
  • ultrasonic focusing
  • array driving system
  • geodesic phased array transducer
  • multiple-channel electronics
  • NI-FlexRIO
  • NIPXIe
  • PMN-PT
  • therapuetic ultrasound
  • ultrasound-mediated targeted drug delivery

Cite this

Qiu, Z., Habeshaw, R., Lines, D., & Cochran, S. (2014). Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array. In 2014 IEEE International Ultrasonics Symposium (pp. 811-814). Piscataway: IEEE. https://doi.org/10.1109/ULTSYM.2014.0199
Qiu, Zhen ; Habeshaw, Roderick ; Lines, Dave ; Cochran, Sandy. / Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array. 2014 IEEE International Ultrasonics Symposium. Piscataway : IEEE, 2014. pp. 811-814
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abstract = "Ultrasound-mediated targeted drug delivery (UmTDD) has the potential to enhance the chemotherapeutic treatment of cancer by allowing increased drug doses preferentially at the location of the tumor. Although gaining increasing interest over the past few years, research into UmTDD system configurations has been hindered by the lack of experimental driving systems and ultrasound devices. In the work reported here, a piezocrystal composite geodesic phased array with 96 elements was connected to commercial programmable multi-channel electronics based on NI-PXIe / FlexRIO-FPGA hardware. The system was modified to provide appropriate ultrasound intensities through power and heat dissipation strategies. Auto-focusing was applied by phase aberration correction. Preliminary results using cross-correlation are presented to demonstrate its applicability. The pressure intensity at the focus of the array was increased four times while the intensity of side lobes were below -12 dB.",
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Qiu, Z, Habeshaw, R, Lines, D & Cochran, S 2014, Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array. in 2014 IEEE International Ultrasonics Symposium. IEEE, Piscataway, pp. 811-814, IEEE 2014 International Ultrasonics Symposium, Chicago, United Kingdom, 3/09/14. https://doi.org/10.1109/ULTSYM.2014.0199

Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array. / Qiu, Zhen; Habeshaw, Roderick; Lines, Dave; Cochran, Sandy.

2014 IEEE International Ultrasonics Symposium. Piscataway : IEEE, 2014. p. 811-814.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Qiu Z, Habeshaw R, Lines D, Cochran S. Customized modular multichannel electronics for ultrasound-mediated targeted drug delivery with a geodesic piezocrystal phased array. In 2014 IEEE International Ultrasonics Symposium. Piscataway: IEEE. 2014. p. 811-814 https://doi.org/10.1109/ULTSYM.2014.0199