Curvedness study on atherosclerosis plaques and its implications to plaque stress

Hao Gao, Quan Long, Martin Graves, Zhiyong Li, Jonathan Gillard

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.
LanguageEnglish
Title of host publicationIFMBE Proceedings
EditorsRatko Magjarevic
PublisherSpringer
Pages1507-1510
Number of pages4
Volume31
Edition6
DOIs
Publication statusPublished - 2010
Event6th world congress of biomechanics (WCB 2010) - , Singapore
Duration: 1 Aug 20106 Aug 2010

Publication series

NameIFMBE Proceedings Series
PublisherSpringer
ISSN (Print)1680-0737

Conference

Conference6th world congress of biomechanics (WCB 2010)
CountrySingapore
Period1/08/106/08/10

Fingerprint

Fluid structure interaction
Stress analysis
Stress concentration

Keywords

  • atherosclerosis plaque
  • stress analysis
  • curvedness

Cite this

Gao, H., Long, Q., Graves, M., Li, Z., & Gillard, J. (2010). Curvedness study on atherosclerosis plaques and its implications to plaque stress. In R. Magjarevic (Ed.), IFMBE Proceedings (6 ed., Vol. 31, pp. 1507-1510). (IFMBE Proceedings Series). Springer. https://doi.org/10.1007/978-3-642-14515-5_384
Gao, Hao ; Long, Quan ; Graves, Martin ; Li, Zhiyong ; Gillard, Jonathan. / Curvedness study on atherosclerosis plaques and its implications to plaque stress. IFMBE Proceedings. editor / Ratko Magjarevic. Vol. 31 6. ed. Springer, 2010. pp. 1507-1510 (IFMBE Proceedings Series).
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title = "Curvedness study on atherosclerosis plaques and its implications to plaque stress",
abstract = "Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.",
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Gao, H, Long, Q, Graves, M, Li, Z & Gillard, J 2010, Curvedness study on atherosclerosis plaques and its implications to plaque stress. in R Magjarevic (ed.), IFMBE Proceedings. 6 edn, vol. 31, IFMBE Proceedings Series, Springer, pp. 1507-1510, 6th world congress of biomechanics (WCB 2010), Singapore, 1/08/10. https://doi.org/10.1007/978-3-642-14515-5_384

Curvedness study on atherosclerosis plaques and its implications to plaque stress. / Gao, Hao; Long, Quan; Graves, Martin; Li, Zhiyong; Gillard, Jonathan.

IFMBE Proceedings. ed. / Ratko Magjarevic. Vol. 31 6. ed. Springer, 2010. p. 1507-1510 (IFMBE Proceedings Series).

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

TY - GEN

T1 - Curvedness study on atherosclerosis plaques and its implications to plaque stress

AU - Gao, Hao

AU - Long, Quan

AU - Graves, Martin

AU - Li, Zhiyong

AU - Gillard, Jonathan

PY - 2010

Y1 - 2010

N2 - Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

AB - Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

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Gao H, Long Q, Graves M, Li Z, Gillard J. Curvedness study on atherosclerosis plaques and its implications to plaque stress. In Magjarevic R, editor, IFMBE Proceedings. 6 ed. Vol. 31. Springer. 2010. p. 1507-1510. (IFMBE Proceedings Series). https://doi.org/10.1007/978-3-642-14515-5_384