Curvedness study on atherosclerosis plaques and its implications to plaque stress

Hao Gao; Quan Long; Martin Graves; Zhiyong Li; Jonathan Gillard

doi:10.1007/978-3-642-14515-5_384

Curvedness study on atherosclerosis plaques and its implications to plaque stress

Hao Gao, Quan Long, Martin Graves, Zhiyong Li, Jonathan Gillard

Electronic And Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

1 Citation (Scopus)

Abstract

Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

Original language	English
Title of host publication	IFMBE Proceedings
Editors	Ratko Magjarevic
Publisher	Springer
Pages	1507-1510
Number of pages	4
Volume	31
Edition	6
DOIs	https://doi.org/10.1007/978-3-642-14515-5_384
Publication status	Published - 2010
Event	6th world congress of biomechanics (WCB 2010) - , Singapore Duration: 1 Aug 2010 → 6 Aug 2010

Publication series

Name	IFMBE Proceedings Series
Publisher	Springer
ISSN (Print)	1680-0737

Conference

Conference	6th world congress of biomechanics (WCB 2010)
Country	Singapore
Period	1/08/10 → 6/08/10

Fingerprint

Keywords

atherosclerosis plaque
stress analysis
curvedness

Cite this

Gao, H., Long, Q., Graves, M., Li, Z., & Gillard, J. (2010). Curvedness study on atherosclerosis plaques and its implications to plaque stress. In R. Magjarevic (Ed.), IFMBE Proceedings (6 ed., Vol. 31, pp. 1507-1510). (IFMBE Proceedings Series). Springer. https://doi.org/10.1007/978-3-642-14515-5_384

@inproceedings{fbce927ff276461f9d1f68600bedac43,

title = "Curvedness study on atherosclerosis plaques and its implications to plaque stress",

abstract = "Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.",

keywords = "atherosclerosis plaque, stress analysis , curvedness",

author = "Hao Gao and Quan Long and Martin Graves and Zhiyong Li and Jonathan Gillard",

year = "2010",

doi = "10.1007/978-3-642-14515-5_384",

language = "English",

volume = "31",

series = "IFMBE Proceedings Series",

publisher = "Springer",

pages = "1507--1510",

editor = "Ratko Magjarevic",

booktitle = "IFMBE Proceedings",

edition = "6",

}

TY - GEN

T1 - Curvedness study on atherosclerosis plaques and its implications to plaque stress

AU - Gao, Hao

AU - Long, Quan

AU - Graves, Martin

AU - Li, Zhiyong

AU - Gillard, Jonathan

PY - 2010

Y1 - 2010

N2 - Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

AB - Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.

KW - atherosclerosis plaque

KW - stress analysis

KW - curvedness

U2 - 10.1007/978-3-642-14515-5_384

DO - 10.1007/978-3-642-14515-5_384

M3 - Conference contribution book

VL - 31

T3 - IFMBE Proceedings Series

SP - 1507

EP - 1510

BT - IFMBE Proceedings

A2 - Magjarevic, Ratko

PB - Springer

ER -

Access to Document

10.1007/978-3-642-14515-5_384