Curvedness study on atherosclerosis plaques and its implications to plaque stress

Hao Gao, Quan Long, Martin Graves, Zhiyong Li, Jonathan Gillard

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)


Atherosclerosis plaque rupture has been considered to be a mechanical failure of the thin fibrous cap, resulted from extreme plaque stress. Plaque stress was affected by many factors from morphological features to biological abnormalities. In this study, geometrical factors (curvedness, fibrous cap thickness) were studied on assessing plaque vulnerability in comparison with stress analysis results obtained by fluid structure interaction from 20 human carotid atherosclerosis plaques. The results show that plaque surface curvedness could contribute to extreme stress level, especially in plaque shoulder region. General plaque stress distribution could be predicted by fibrous cap thickness and curvedness with multi-regression model. With more features included in the regression model, plaque stress could be easily calculated and used to assess plaque vulnerability.
Original languageEnglish
Title of host publicationIFMBE Proceedings
EditorsRatko Magjarevic
Number of pages4
Publication statusPublished - 2010
Event6th world congress of biomechanics (WCB 2010) - , Singapore
Duration: 1 Aug 20106 Aug 2010

Publication series

NameIFMBE Proceedings Series
ISSN (Print)1680-0737


Conference6th world congress of biomechanics (WCB 2010)



  • atherosclerosis plaque
  • stress analysis
  • curvedness

Cite this

Gao, H., Long, Q., Graves, M., Li, Z., & Gillard, J. (2010). Curvedness study on atherosclerosis plaques and its implications to plaque stress. In R. Magjarevic (Ed.), IFMBE Proceedings (6 ed., Vol. 31, pp. 1507-1510). (IFMBE Proceedings Series). Springer.