Current utilization patterns for long-acting insulin analogues including biosimilars among selected Asian countries and the implications for the future

Brian Godman, Mainul Haque, Santosh Kumar, Salequl Islam, Jaykaran Charan, Farhana Akter, Amanj Kurdi, Eleonora Allocati, Muhammed Abu Bakar, Sagir Abdur Rahim, Nusrat Sultana, Farzana Deeba, MA Halim Khan, ABM Muksudul Alam, Iffat Jahan, Zubair Mahmood Kamal, Humaira Hasin, Munzur-E Murshid, Shamsun Nahar, Monami HaqueSiddhartha Dutta, Jha Pallavi Abhayanand, Rimple Jeet Kaur, Jitendra Acharya, Takuma Sugahara, Hye-Young Kwon, SeungJin Bae, Karen Koh Pek Khuan, Tanveer Ahmed Khan, Shahzad Hussain, Zikria Saleem, Alice Pisana, Janney Wale, Mihajlo Jakovljevi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Prevalence rates for diabetes mellitus continue to rise, which, coupled with increasing costs of complications, has appreciably increased expenditure in recent years. Poor glycaemic control including hypoglycaemia enhances complication rates and associated morbidity, mortality and costs. Consequently, this needs to be addressed. Whilst the majority of patients with diabetes have type-2 diabetes, a considerable number of patients with diabetes require insulin to help control their diabetes. Long-acting insulin analogues were developed to reduce hypoglycaemia associated with insulin and help improve adherence, which can be a concern. However, their considerably higher costs have impacted on their funding and use, especially in countries with affordability issues. Biosimilars can help reduce the costs of long-acting insulin analogues thereby increasing available choices. However, the availability and use of long-acting insulin analogues can be affected by limited price reductions versus originators and limited demand-side initiatives to encourage their use. Consequently, we wanted to assess current utilisation rates for long-acting insulin analogues, especially biosimilars, and the rationale for patterns seen, across multiple Asian countries ranging from Japan (high-income) to Pakistan (lower-income) to inform future strategies. Methodology: Multiple approaches including assessing utilization and prices of insulins including biosimilars among six Asian countries and comparing the findings especially with other middle-income countries. Results: Typically, there was increasing use of long-acting insulin analogues among the selected Asian countries. This was especially the case enhanced by biosimilars in Bangladesh, India, and Malaysia reflecting their perceived benefits. However, there was limited use in Pakistan due to issues of affordability similar to a number of African countries. The high use of biosimilars in Bangladesh, India and Malaysia was helped by issues of affordability and local production. The limited use of biosimilars in Japan and Korea reflects limited price reductions and demand-side initiatives similar to a number of European countries. Conclusions: Increasing use of long-acting insulin analogues across countries is welcomed, adding to the range of insulins available, which increasingly includes biosimilars. A number of activities are needed to enhance the use of long-acting insulin analogue biosimilars in Japan, Korea and Pakistan.

Original languageEnglish
Pages (from-to)1529-1545
Number of pages17
JournalCurrent Medical Research and Opinion
Volume37
Issue number9
Early online date24 Jun 2021
DOIs
Publication statusPublished - 24 Aug 2021

Keywords

  • Asia
  • biosimilars
  • insulins
  • diabetes
  • long-acting insulin analogues
  • health policies
  • Bangladesh

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