Current trends in electrochemical approaches for liver biomarker detection: a mini-review

Derya Yaman, Melanie Jimenez, Sofia Ferreira-Gonazalez, Damion Corrigan

Research output: Contribution to journalReview articlepeer-review

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Abstract

Aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and albumin are well-established liver biomarkers with significant physiological functions. Alterations in these liver function tests can be indicative of the presence and progression of acute and chronic liver conditions such as liver cirrhosis, non-alcoholic fatty liver disease, biliary disease, and liver failure. Therefore, accurate and quantitative detection of these biomarkers is crucial for diagnosing and monitoring liver disease. There are several commercially available chemistry analyzers capable of simultaneously detecting all these biomarkers, as well as numerous biosensors designed for individual detection. Various techniques have been employed, including colorimetry, surface-enhanced Raman spectroscopy (SERS), electrochemiluminescence (ECL), fluorescence-based techniques, and electrochemical methods. Among these, electrochemical detection stands out due to its simplicity, cost-effectiveness, low sample volume requirement, label-free detection, high sensitivity, fast response times, miniaturization, and portability. Information on recently developed electrochemical biosensors is summarized through detailed tables and is intended to guide future research and development efforts in this area.
Original languageEnglish
Pages (from-to)5156-5164
Number of pages9
JournalAnalyst
Volume149
Issue number21
Early online date23 Sept 2024
DOIs
Publication statusE-pub ahead of print - 23 Sept 2024

Keywords

  • liver biomarkers
  • liver function tests
  • liver disease
  • electrochemical detection
  • electrochemical biosensors

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