Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine

Abeer Alghamdi, Thorben Wellbrock, David J.S. Birch, Vladislav Vyshemirsky, Olaf J. Rolinski

Research output: Contribution to journalArticle

Abstract

A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.
LanguageEnglish
Number of pages8
JournalChemPhysChem
Early online date20 Sep 2019
DOIs
Publication statusE-pub ahead of print - 20 Sep 2019

Fingerprint

Oligomerization
tyrosine
Amyloid
peptides
Tyrosine
Copper
Agglomeration
Fluorescence
copper
fluorescence
Peptides
spectral emission
Amyloid beta-Peptides
Ions
shift
ions

Keywords

  • Alzheimer disease
  • beta-amyloid aggregation
  • intrinsic fluorescence
  • copper-beta amyloid interaction
  • time-resolved emission spectra

Cite this

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title = "Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine",
abstract = "A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.",
keywords = "Alzheimer disease, beta-amyloid aggregation, intrinsic fluorescence, copper-beta amyloid interaction, time-resolved emission spectra",
author = "Abeer Alghamdi and Thorben Wellbrock and Birch, {David J.S.} and Vladislav Vyshemirsky and Rolinski, {Olaf J.}",
year = "2019",
month = "9",
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doi = "10.1002/cphc.201900565",
language = "English",
journal = "ChemPhysChem",
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Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine. / Alghamdi, Abeer; Wellbrock, Thorben; Birch, David J.S.; Vyshemirsky, Vladislav; Rolinski, Olaf J.

In: ChemPhysChem, 20.09.2019.

Research output: Contribution to journalArticle

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AU - Wellbrock, Thorben

AU - Birch, David J.S.

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AU - Rolinski, Olaf J.

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AB - A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

KW - Alzheimer disease

KW - beta-amyloid aggregation

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