Cu2+ effects on beta‐amyloid oligomerisation monitored by fluorescence of intrinsic tyrosine

Abeer Alghamdi, Thorben Wellbrock, David J.S. Birch, Vladislav Vyshemirsky, Olaf J. Rolinski

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Abstract

A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.
Original languageEnglish
Pages (from-to)3181-3185
Number of pages5
JournalChemPhysChem
Volume20
Issue number23
Early online date20 Sep 2019
DOIs
Publication statusPublished - 3 Dec 2019

Keywords

  • Alzheimer disease
  • beta-amyloid aggregation
  • intrinsic fluorescence
  • copper-beta amyloid interaction
  • time-resolved emission spectra

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    Olaf Rolinski

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