Cu            2+ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine

Abeer Alghamdi; Thorben Wellbrock; David J.S. Birch; Vladislav Vyshemirsky; Olaf J. Rolinski

doi:10.1002/cphc.201900565

Cu ²⁺ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine

Abeer Alghamdi, Thorben Wellbrock, David J.S. Birch, Vladislav Vyshemirsky, Olaf J. Rolinski

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Abstract

A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

Original language	English
Pages (from-to)	3181-3185
Number of pages	5
Journal	ChemPhysChem
Volume	20
Issue number	23
Early online date	20 Sept 2019
DOIs	https://doi.org/10.1002/cphc.201900565
Publication status	Published - 3 Dec 2019

Keywords

Alzheimer disease
beta-amyloid aggregation
intrinsic fluorescence
copper-beta amyloid interaction
time-resolved emission spectra

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Alghamdi-etal-CPC-2019-oligomerisation-monitored-by-fluorescence-of-intrinsic-tyrosineAccepted author manuscript, 1.54 MB

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title = "Cu 2+ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine",

abstract = "A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer{\textquoteright}s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.",

keywords = "Alzheimer disease, beta-amyloid aggregation, intrinsic fluorescence, copper-beta amyloid interaction, time-resolved emission spectra",

author = "Abeer Alghamdi and Thorben Wellbrock and Birch, {David J.S.} and Vladislav Vyshemirsky and Rolinski, {Olaf J.}",

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T1 - Cu 2+ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine

AU - Alghamdi, Abeer

AU - Wellbrock, Thorben

AU - Birch, David J.S.

AU - Vyshemirsky, Vladislav

AU - Rolinski, Olaf J.

PY - 2019/12/3

Y1 - 2019/12/3

N2 - A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

AB - A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer’s beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.

KW - Alzheimer disease

KW - beta-amyloid aggregation

KW - intrinsic fluorescence

KW - copper-beta amyloid interaction

KW - time-resolved emission spectra

U2 - 10.1002/cphc.201900565

DO - 10.1002/cphc.201900565

M3 - Article

SN - 1439-4235

VL - 20

SP - 3181

EP - 3185

JO - ChemPhysChem

JF - ChemPhysChem

IS - 23

ER -

Cu 2+ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine

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Keywords

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Cu ²⁺ effects on beta-amyloid oligomerisation monitored by the fluorescence of intrinsic tyrosine